Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2191634..2192502 | Replicon | chromosome |
| Accession | NZ_CP095023 | ||
| Organism | Mycobacterium tuberculosis strain SGF0702019 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | MUW68_RS10210 | Protein ID | WP_162470919.1 |
| Coordinates | 2191634..2192011 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | MUW68_RS10215 | Protein ID | WP_003409886.1 |
| Coordinates | 2192053..2192502 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW68_RS10160 (MUW68_10160) | 2187423..2187875 | - | 453 | WP_003899095.1 | lipoprotein | - |
| MUW68_RS10165 (MUW68_10165) | 2187939..2188340 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| MUW68_RS10170 (MUW68_10170) | 2188333..2188515 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| MUW68_RS10175 (MUW68_10175) | 2188629..2188979 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| MUW68_RS10180 (MUW68_10180) | 2188990..2189892 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| MUW68_RS10185 (MUW68_10185) | 2189913..2190104 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| MUW68_RS10190 (MUW68_10190) | 2190105..2190401 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| MUW68_RS10195 (MUW68_10195) | 2190641..2190856 | + | 216 | WP_003409878.1 | antitoxin | - |
| MUW68_RS10200 (MUW68_10200) | 2190853..2191164 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUW68_RS10205 (MUW68_10205) | 2191138..2191659 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| MUW68_RS10210 (MUW68_10210) | 2191634..2192011 | + | 378 | WP_162470919.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| MUW68_RS10215 (MUW68_10215) | 2192053..2192502 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| MUW68_RS10220 (MUW68_10220) | 2192499..2193044 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| MUW68_RS10225 (MUW68_10225) | 2192933..2193547 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| MUW68_RS10230 (MUW68_10230) | 2193596..2193892 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MUW68_RS10235 (MUW68_10235) | 2193889..2194140 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| MUW68_RS10240 (MUW68_10240) | 2194127..2194621 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| MUW68_RS10245 (MUW68_10245) | 2194781..2195188 | - | 408 | WP_024754015.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUW68_RS10250 (MUW68_10250) | 2195192..2195464 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MUW68_RS10255 (MUW68_10255) | 2195497..2196717 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14411.80 Da Isoelectric Point: 10.8862
>T241161 WP_162470919.1 NZ_CP095023:2191634-2192011 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFEKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFEKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T241161 NZ_LT907990:425870-426172 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT241161 WP_003409886.1 NZ_CP095023:2192053-2192502 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT241161 NZ_LT907990:425625-425882 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|