Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3803476..3804143 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag MUW67_RS17920 Protein ID WP_003417916.1
Coordinates 3803476..3803868 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag MUW67_RS17925 Protein ID WP_003912214.1
Coordinates 3803868..3804143 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS17900 (MUW67_17900) 3799323..3800312 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MUW67_RS17905 (MUW67_17905) 3800312..3800701 - 390 Protein_3535 polyprenyl synthetase family protein -
MUW67_RS17910 (MUW67_17910) 3800754..3802015 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
MUW67_RS17915 (MUW67_17915) 3802057..3802722 - 666 Protein_3537 polyprenyl synthetase family protein -
MUW67_RS17920 (MUW67_17920) 3803476..3803868 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW67_RS17925 (MUW67_17925) 3803868..3804143 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUW67_RS17930 (MUW67_17930) 3804325..3805696 + 1372 Protein_3540 ISNCY family transposase -
MUW67_RS17935 (MUW67_17935) 3805886..3808063 + 2178 WP_016330440.1 PE family protein -
MUW67_RS17940 (MUW67_17940) 3808134..3809006 - 873 WP_003906098.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3800754..3805696 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T241128 WP_003417916.1 NZ_CP095022:c3803868-3803476 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T241128 NZ_LT906615:420239-420526 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT241128 WP_003912214.1 NZ_CP095022:c3804143-3803868 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT241128 NZ_LT906615:419998-420249 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References