Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2972292..2972940 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag MUW67_RS14040 Protein ID WP_003899414.1
Coordinates 2972292..2972615 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag MUW67_RS14045 Protein ID WP_003899415.1
Coordinates 2972695..2972940 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS14010 (MUW67_14010) 2967615..2968613 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
MUW67_RS14015 (MUW67_14015) 2968627..2969091 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
MUW67_RS14020 (MUW67_14020) 2969079..2969330 + 252 WP_003908028.1 hypothetical protein -
MUW67_RS14025 (MUW67_14025) 2969501..2970940 - 1440 WP_003901443.1 phage major capsid protein -
MUW67_RS14030 (MUW67_14030) 2970948..2971481 - 534 WP_003899412.1 HK97 family phage prohead protease -
MUW67_RS14035 (MUW67_14035) 2971634..2972125 - 492 WP_003900541.1 phage terminase small subunit P27 family -
MUW67_RS14040 (MUW67_14040) 2972292..2972615 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
MUW67_RS14045 (MUW67_14045) 2972695..2972940 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
MUW67_RS14050 (MUW67_14050) 2972937..2974364 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
MUW67_RS14055 (MUW67_14055) 2974366..2974758 - 393 WP_003899417.1 DUF2742 domain-containing protein -
MUW67_RS14060 (MUW67_14060) 2974755..2975015 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
MUW67_RS14065 (MUW67_14065) 2975032..2975394 - 363 WP_003900543.1 hypothetical protein -
MUW67_RS14070 (MUW67_14070) 2975397..2976524 - 1128 WP_003899420.1 site-specific integrase -
MUW67_RS14075 (MUW67_14075) 2976669..2976896 - 228 WP_003899421.1 hypothetical protein -
MUW67_RS14080 (MUW67_14080) 2976893..2977282 - 390 WP_003899422.1 hypothetical protein -
MUW67_RS14085 (MUW67_14085) 2977188..2977460 + 273 WP_003900544.1 hypothetical protein -
MUW67_RS14090 (MUW67_14090) 2977559..2977792 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2967615..2976524 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T241117 WP_003899414.1 NZ_CP095022:c2972615-2972292 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T241117 NZ_LT906615:c322999-322682 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT241117 WP_003899415.1 NZ_CP095022:c2972940-2972695 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT241117 NZ_LT906615:c323260-323018 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References