Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2188408..2189276 | Replicon | chromosome |
| Accession | NZ_CP095022 | ||
| Organism | Mycobacterium tuberculosis strain SGF0472017 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | MUW67_RS10220 | Protein ID | WP_010886136.1 |
| Coordinates | 2188408..2188785 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | MUW67_RS10225 | Protein ID | WP_003409886.1 |
| Coordinates | 2188827..2189276 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW67_RS10170 (MUW67_10170) | 2184197..2184649 | - | 453 | WP_003899095.1 | lipoprotein | - |
| MUW67_RS10175 (MUW67_10175) | 2184713..2185114 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| MUW67_RS10180 (MUW67_10180) | 2185107..2185289 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| MUW67_RS10185 (MUW67_10185) | 2185403..2185753 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| MUW67_RS10190 (MUW67_10190) | 2185764..2186666 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| MUW67_RS10195 (MUW67_10195) | 2186687..2186878 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| MUW67_RS10200 (MUW67_10200) | 2186879..2187175 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| MUW67_RS10205 (MUW67_10205) | 2187415..2187630 | + | 216 | WP_003409878.1 | antitoxin | - |
| MUW67_RS10210 (MUW67_10210) | 2187627..2187938 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUW67_RS10215 (MUW67_10215) | 2187912..2188433 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| MUW67_RS10220 (MUW67_10220) | 2188408..2188785 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| MUW67_RS10225 (MUW67_10225) | 2188827..2189276 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| MUW67_RS10230 (MUW67_10230) | 2189273..2189818 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| MUW67_RS10235 (MUW67_10235) | 2189707..2190321 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| MUW67_RS10240 (MUW67_10240) | 2190370..2190666 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MUW67_RS10245 (MUW67_10245) | 2190663..2190914 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| MUW67_RS10250 (MUW67_10250) | 2190901..2191395 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| MUW67_RS10255 (MUW67_10255) | 2191555..2191962 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUW67_RS10260 (MUW67_10260) | 2191966..2192238 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MUW67_RS10265 (MUW67_10265) | 2192271..2193491 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T241101 WP_010886136.1 NZ_CP095022:2188408-2188785 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T241101 NZ_LT906479:c1218714-1218511 [Serratia ficaria]
ATGACAAAAATCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACGCTTGAACGTGTTATTGAGAAAAATAA
GTATGAACTTTCCGATGATGAGCTGGAGCTGTTTTACTCCGCCGCCGATCACCGCCTGGCAGAGCTCACCATGAACAAAC
TGTACGATAAAATCCCCACCGCCGTTTGGAAGTATGTACGTTAA
ATGACAAAAATCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACGCTTGAACGTGTTATTGAGAAAAATAA
GTATGAACTTTCCGATGATGAGCTGGAGCTGTTTTACTCCGCCGCCGATCACCGCCTGGCAGAGCTCACCATGAACAAAC
TGTACGATAAAATCCCCACCGCCGTTTGGAAGTATGTACGTTAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT241101 WP_003409886.1 NZ_CP095022:2188827-2189276 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT241101 NZ_LT906479:c1219134-1218766 [Serratia ficaria]
ATGGATGAGTATTCGCCTAAGCGGCATGATATTGCTCAACTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATCGC
AACCCTGGGAGACAGCCACCACGGTTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGATCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGTTGTTTAGCAGCTACGGTATCAATGACTCCGACCTTCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG
ATGGATGAGTATTCGCCTAAGCGGCATGATATTGCTCAACTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATCGC
AACCCTGGGAGACAGCCACCACGGTTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGATCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGTTGTTTAGCAGCTACGGTATCAATGACTCCGACCTTCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|