Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2188408..2189276 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag MUW67_RS10220 Protein ID WP_010886136.1
Coordinates 2188408..2188785 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag MUW67_RS10225 Protein ID WP_003409886.1
Coordinates 2188827..2189276 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T241101 WP_010886136.1 NZ_CP095022:2188408-2188785 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T241101 NZ_LT906479:c1218714-1218511 [Serratia ficaria]
ATGACAAAAATCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACGCTTGAACGTGTTATTGAGAAAAATAA
GTATGAACTTTCCGATGATGAGCTGGAGCTGTTTTACTCCGCCGCCGATCACCGCCTGGCAGAGCTCACCATGAACAAAC
TGTACGATAAAATCCCCACCGCCGTTTGGAAGTATGTACGTTAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT241101 WP_003409886.1 NZ_CP095022:2188827-2189276 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT241101 NZ_LT906479:c1219134-1218766 [Serratia ficaria]
ATGGATGAGTATTCGCCTAAGCGGCATGATATTGCTCAACTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATCGC
AACCCTGGGAGACAGCCACCACGGTTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGATCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGTTGTTTAGCAGCTACGGTATCAATGACTCCGACCTTCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References