Detailed information of TA system TA024106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 4122831..4123682
• Replicon: chromosome
• Accession: NC_012962
• Organism: Photorhabdus asymbiotica

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: PAU_RS17405
• Protein ID: WP_015835635.1
• Coordinates: 4123188..4123682 (+)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: PAU_RS17400
• Protein ID: WP_015835634.1
• Coordinates: 4122831..4123181 (+)
• Length: 117 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAU_RS17380	4118050..4118958	+	909	WP_015835630.1	hypothetical protein	-
PAU_RS17385	4119626..4120051	-	426	WP_015835631.1	TonB system transport protein ExbD	-
PAU_RS17390	4120056..4121027	-	972	WP_041382976.1	tonB-system energizer ExbB	-
PAU_RS17395	4121506..4122699	+	1194	WP_015835633.1	cystathionine beta-lyase	-
PAU_RS17400	4122831..4123181	+	351	WP_015835634.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
PAU_RS17405	4123188..4123682	+	495	WP_015835635.1	type II toxin-antitoxin system YhaV family toxin	Toxin
PAU_RS17410	4123805..4124255	-	451	Protein_3438	helix-turn-helix domain-containing protein	-
PAU_RS23360	4124349..4124550	+	202	Protein_3439	transposase	-
PAU_RS17415	4124727..4125398	+	672	WP_015835638.1	DedA family protein	-
PAU_RS17420	4125658..4126527	+	870	WP_015835639.1	2,5-didehydrogluconate reductase DkgA	-
PAU_RS17425	4126645..4128060	-	1416	WP_015835641.1	cell division protein FtsP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4123766..4124071	305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (13-149)

Antitoxin

• PrlF antitoxin (14-114)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 19449.40 Da
• Isoelectric Point: 9.5245

>T24106 WP_015835635.1 NC_012962:4123188-4123682 [Photorhabdus asymbiotica]
MYDRVCVINGWVLFAHPCFIEQLKQIIDKVEQLQQKYPNDYLKKNDTKRLAAIIKLVTEIIPSDPANITFRLGYTLGGKR
KHWFRAKFFQQYRLFFRFHTESKIIIFGWVNDDRTKRAYGDQRDAYKVFGEMLNAGRPPDDWTSLLKESIESPHLAELLN
EHQP

Nucleotide

• Length: 495 bp

>T24106 NC_012962:4123188-4123682 [Photorhabdus asymbiotica]
ATGTACGATCGAGTATGTGTAATAAACGGATGGGTTCTTTTTGCCCATCCGTGCTTTATAGAACAACTGAAACAAATAAT
AGACAAGGTCGAACAACTTCAGCAGAAATATCCAAATGACTATCTGAAAAAAAATGATACGAAACGCTTAGCTGCAATCA
TAAAACTTGTTACTGAAATTATTCCCAGTGACCCCGCTAATATAACCTTTCGTTTGGGTTACACATTAGGCGGAAAAAGA
AAACACTGGTTCAGAGCAAAATTTTTCCAACAATATCGCCTTTTCTTCCGTTTTCACACCGAGAGTAAAATTATTATCTT
TGGCTGGGTAAATGATGACAGAACAAAAAGGGCATATGGTGATCAACGTGATGCTTACAAAGTATTTGGTGAAATGCTTA
ACGCTGGACGCCCACCAGATGACTGGACTTCTCTTTTAAAGGAATCAATTGAATCACCACACTTAGCTGAACTTCTTAAT
GAACACCAACCATAA

Antitoxin

Protein

• Length: 117 a.a.
• Molecular weight: 13016.63 Da
• Isoelectric Point: 5.6953

>AT24106 WP_015835634.1 NC_012962:4122831-4123181 [Photorhabdus asymbiotica]
MHESSSVEFDVGAESKLTRRSQTTIPTPVRKALKLRPGHDSIKYKILSSGDVLISRKSSEEEKDPVIESFLNFLEKDIKK
HPEQIQQLSEQLINRAKSLTAGTDIDLNNPLSADDE

Nucleotide

• Length: 351 bp

>AT24106 NC_012962:4122831-4123181 [Photorhabdus asymbiotica]
ATGCACGAATCATCAAGTGTTGAGTTCGATGTTGGAGCAGAATCCAAACTTACCCGTCGCAGCCAAACAACTATTCCAAC
GCCAGTCCGTAAAGCTCTTAAACTAAGACCTGGACATGATAGTATCAAATATAAGATTTTATCTTCTGGTGATGTACTTA
TCAGTCGTAAAAGCAGCGAAGAAGAAAAAGATCCTGTAATAGAATCATTTCTGAACTTTCTGGAAAAAGACATTAAAAAA
CATCCTGAACAAATACAACAATTAAGTGAACAACTCATTAACCGAGCAAAGTCACTTACTGCTGGGACAGACATAGATCT
AAATAATCCACTATCTGCCGACGATGAGTAA