Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2965744..2966392 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag MUW66_RS14000 Protein ID WP_003899414.1
Coordinates 2965744..2966067 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag MUW66_RS14005 Protein ID WP_003899415.1
Coordinates 2966147..2966392 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS13970 (MUW66_13970) 2961067..2962065 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
MUW66_RS13975 (MUW66_13975) 2962079..2962543 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
MUW66_RS13980 (MUW66_13980) 2962531..2962782 + 252 WP_003908028.1 hypothetical protein -
MUW66_RS13985 (MUW66_13985) 2962953..2964392 - 1440 WP_003901443.1 phage major capsid protein -
MUW66_RS13990 (MUW66_13990) 2964400..2964933 - 534 WP_244743666.1 HK97 family phage prohead protease -
MUW66_RS13995 (MUW66_13995) 2965086..2965577 - 492 WP_003900541.1 phage terminase small subunit P27 family -
MUW66_RS14000 (MUW66_14000) 2965744..2966067 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
MUW66_RS14005 (MUW66_14005) 2966147..2966392 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
MUW66_RS14010 (MUW66_14010) 2966389..2967816 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
MUW66_RS14015 (MUW66_14015) 2967818..2968210 - 393 WP_003899417.1 DUF2742 domain-containing protein -
MUW66_RS14020 (MUW66_14020) 2968207..2968467 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
MUW66_RS14025 (MUW66_14025) 2968484..2968846 - 363 WP_003900543.1 hypothetical protein -
MUW66_RS14030 (MUW66_14030) 2968849..2969976 - 1128 WP_003899420.1 site-specific integrase -
MUW66_RS14035 (MUW66_14035) 2970121..2970348 - 228 WP_003899421.1 hypothetical protein -
MUW66_RS14040 (MUW66_14040) 2970345..2970734 - 390 WP_003899422.1 hypothetical protein -
MUW66_RS14045 (MUW66_14045) 2970640..2970912 + 273 WP_003900544.1 hypothetical protein -
MUW66_RS14050 (MUW66_14050) 2971011..2971244 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2961067..2969976 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T241057 WP_003899414.1 NZ_CP095021:c2966067-2965744 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T241057 NZ_LT906462:c79937-79842 [Mammaliicoccus stepanovicii]
ATATTGGAAATCCTTGTTCACATCATGACTACAGTCATCAGTGGCTGTACTATTGCGTTATTTACGCATTGGCTACGTAA
GCGCAATGACAAATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT241057 WP_003899415.1 NZ_CP095021:c2966392-2966147 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT241057 NZ_LT906462:c79824-79789 [Mammaliicoccus stepanovicii]
TACAAAAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References