Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2189812..2190656 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name higB Uniprot ID A0A045JPD9
Locus tag MUW66_RS10210 Protein ID WP_003905702.1
Coordinates 2189812..2190165 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag MUW66_RS10215 Protein ID WP_003409886.1
Coordinates 2190207..2190656 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS10160 (MUW66_10160) 2185576..2186028 - 453 WP_003899095.1 lipoprotein -
MUW66_RS10165 (MUW66_10165) 2186092..2186493 + 402 WP_003409869.1 hypothetical protein -
MUW66_RS10170 (MUW66_10170) 2186486..2186668 - 183 WP_003409870.1 hypothetical protein -
MUW66_RS10175 (MUW66_10175) 2186782..2187132 - 351 WP_003409871.1 hypothetical protein -
MUW66_RS10180 (MUW66_10180) 2187143..2188045 - 903 WP_003899097.1 hypothetical protein -
MUW66_RS10185 (MUW66_10185) 2188066..2188257 - 192 WP_003409876.1 hypothetical protein -
MUW66_RS10190 (MUW66_10190) 2188258..2188554 - 297 WP_003409877.1 hypothetical protein -
MUW66_RS10195 (MUW66_10195) 2188794..2189009 + 216 WP_003409878.1 antitoxin -
MUW66_RS10200 (MUW66_10200) 2189006..2189317 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
MUW66_RS10205 (MUW66_10205) 2189291..2189839 - 549 WP_244743795.1 hypothetical protein -
MUW66_RS10210 (MUW66_10210) 2189812..2190165 + 354 WP_003905702.1 type II toxin-antitoxin system toxin HigB Toxin
MUW66_RS10215 (MUW66_10215) 2190207..2190656 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
MUW66_RS10220 (MUW66_10220) 2190653..2191198 + 546 WP_003409891.1 SecB-like chaperone -
MUW66_RS10225 (MUW66_10225) 2191087..2191701 - 615 WP_003901296.1 hypothetical protein -
MUW66_RS10230 (MUW66_10230) 2191750..2192046 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
MUW66_RS10235 (MUW66_10235) 2192043..2192294 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
MUW66_RS10240 (MUW66_10240) 2192281..2192775 + 495 WP_003899099.1 hypothetical protein -
MUW66_RS10245 (MUW66_10245) 2192935..2193342 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
MUW66_RS10250 (MUW66_10250) 2193346..2193618 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MUW66_RS10255 (MUW66_10255) 2193651..2194871 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13652.93 Da        Isoelectric Point: 11.0242

>T241041 WP_003905702.1 NZ_CP095021:2189812-2190165 [Mycobacterium tuberculosis]
MGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLFFRWGQHPV
ALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 354 bp

>T241041 NZ_LT906456:90292-90714 [Actinobacillus suis]
ATGTATTTATTAGATACCAATATTGTTTCCGAACTACGTAAAATGGAAAGTGGAAAAGCTGATGTTAATGTGGTTGCCTG
GTTTCAACAAGTCAATTTAACCGATGCTTATTTAAGTGTTATCACTCTCTTTGAAATTAAGTTAGGTATTTTGCAACTTA
AACGCAAAGATATTCAACAAGCTAAACTTTTACAAAGTTGGTTTGAACAAAAACTTTTACATCATTTTGAAAATAGAATT
TTACCGCTTGATACCAAAGTTATGATGATCTGTGCAGAGTTTCATATTCCGGATAAAAAGCCGTTAAATGACTCTTATAT
AGCCGCTACGGCTAAAGCACATAGATTTAAAATTGTGACGAGAAATGTGAAAAATTTTAAAGGATGTGGGGTAGAGGTAC
TGAATCCATTTATTGATGAATAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT241041 WP_003409886.1 NZ_CP095021:2190207-2190656 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT241041 NZ_LT906456:90005-90292 [Actinobacillus suis]
ATGGCGGTCATCAGTTCCAAAGAATTTAACCAACGTGCCAGTGCTGTATTAAAAATTGCAGAAACCGAGCCTGTGTATAT
TACTAAATGGGGTAAGGTGGTTAGTGTGTTGGCAAGCTACGCTCATTATCAAGCTCAAACGAAATCGCAAAGTTTGGCAG
ATGCTTTTAGCAGTACGGTACCAACTGCAATATTGAGTACCGAAGCCGAACAGCAATTTGAGCAAACTTTGCAGCAAATA
CGTCAACAAAGCAAAATGAACGTACCGGATTTATCGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045JPD9

Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References