Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2260549..2261468 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag MUW65_RS10620 Protein ID WP_024753682.1
Coordinates 2260863..2261468 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag MUW65_RS10615 Protein ID WP_003410124.1
Coordinates 2260549..2260854 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS10580 (MUW65_10580) 2255812..2256012 + 201 Protein_2091 hypothetical protein -
MUW65_RS10590 (MUW65_10590) 2257368..2257745 + 378 Protein_2093 hypothetical protein -
MUW65_RS10595 (MUW65_10595) 2257742..2258782 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
MUW65_RS10600 (MUW65_10600) 2259024..2259743 + 720 WP_003410108.1 DUF433 domain-containing protein -
MUW65_RS10605 (MUW65_10605) 2259733..2260149 + 417 WP_003410114.1 hypothetical protein -
MUW65_RS10610 (MUW65_10610) 2260165..2260464 - 300 WP_003410120.1 hypothetical protein -
MUW65_RS10615 (MUW65_10615) 2260549..2260854 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
MUW65_RS10620 (MUW65_10620) 2260863..2261468 - 606 WP_024753682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUW65_RS10625 (MUW65_10625) 2261493..2261852 - 360 WP_003410131.1 hypothetical protein -
MUW65_RS10630 (MUW65_10630) 2262012..2262602 - 591 WP_223695536.1 hypothetical protein -
MUW65_RS10635 (MUW65_10635) 2262641..2262877 - 237 WP_003410133.1 hypothetical protein -
MUW65_RS10640 (MUW65_10640) 2263084..2263980 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22743.97 Da        Isoelectric Point: 7.6272

>T240987 WP_024753682.1 NZ_CP095020:c2261468-2260863 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGNEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

>T240987 NZ_LT903847:2654025-2654276 [Escherichia coli O127:H6]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT240987 WP_003410124.1 NZ_CP095020:c2260854-2260549 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT240987 NZ_LT903847:2654273-2654527 [Escherichia coli O127:H6]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References