Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2615942..2616468 Replicon chromosome
Accession NZ_CP095011
Organism Streptomyces sp. 2P-4

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUK52_RS10965 Protein ID WP_284575788.1
Coordinates 2615942..2616196 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUK52_RS10970 Protein ID WP_284575789.1
Coordinates 2616193..2616468 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUK52_RS10945 2611288..2612397 - 1110 WP_284575785.1 alpha/beta hydrolase-fold protein -
MUK52_RS10950 2612596..2613636 - 1041 WP_246042773.1 alpha/beta hydrolase-fold protein -
MUK52_RS10955 2614125..2614562 - 438 WP_174250342.1 MarR family transcriptional regulator -
MUK52_RS10960 2614640..2615650 + 1011 WP_284575787.1 SMP-30/gluconolactonase/LRE family protein -
MUK52_RS10965 2615942..2616196 - 255 WP_284575788.1 Txe/YoeB family addiction module toxin Toxin
MUK52_RS10970 2616193..2616468 - 276 WP_284575789.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MUK52_RS10975 2616866..2617243 + 378 WP_284575791.1 CPCC family cysteine-rich protein -
MUK52_RS10980 2617240..2617980 + 741 WP_284575792.1 HEAT repeat domain-containing protein -
MUK52_RS10985 2617984..2618619 + 636 WP_284575793.1 DUF6000 family protein -
MUK52_RS10990 2618681..2619820 - 1140 WP_284575794.1 Fic family protein -
MUK52_RS10995 2620172..2620441 + 270 WP_114053981.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MUK52_RS11000 2620434..2620697 + 264 WP_284575796.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.65 Da        Isoelectric Point: 9.7600

>T240945 WP_284575788.1 NZ_CP095011:c2616196-2615942 [Streptomyces sp. 2P-4]
VRLVFEDQGWEDYTSWLKNDRKMLARINRLIEDVRRDPFTGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTGKEIVILAA
RYRY

Download         Length: 255 bp

>T240945 NZ_LT883143:c141949-141668 [Pseudomonas aeruginosa C-NN2]
ATGAGCCTGAAGTGGACCCGTAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGAAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9922.16 Da        Isoelectric Point: 5.1373

>AT240945 WP_284575789.1 NZ_CP095011:c2616468-2616193 [Streptomyces sp. 2P-4]
MSITASEARKELFPLIKKVNENHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALANINVSEREL
IDPDSADTGAA

Download         Length: 276 bp

>AT240945 NZ_LT883143:c142173-141946 [Pseudomonas aeruginosa C-NN2]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCGGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References