Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 55714..55978 | Replicon | plasmid pS3160_2 |
| Accession | NZ_CP094989 | ||
| Organism | Shigella flexneri strain 3160_NCHU22 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | MT485_RS24960 | Protein ID | WP_001331364.1 |
| Coordinates | 55826..55978 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 55714..55771 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MT485_RS24945 (50953) | 50953..53244 | - | 2292 | WP_001289276.1 | F-type conjugative transfer protein TrbC | - |
| MT485_RS24950 (53237) | 53237..54307 | - | 1071 | WP_000151583.1 | IncI1-type conjugal transfer protein TrbB | - |
| MT485_RS24955 (54326) | 54326..55534 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (55714) | 55714..55771 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (55714) | 55714..55771 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (55714) | 55714..55771 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (55714) | 55714..55771 | - | 58 | NuclAT_0 | - | Antitoxin |
| MT485_RS24960 (55826) | 55826..55978 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| MT485_RS24965 (56050) | 56050..56301 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| MT485_RS25335 (56800) | 56800..56895 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| MT485_RS24975 (56960) | 56960..57136 | - | 177 | WP_001054904.1 | hypothetical protein | - |
| MT485_RS24980 (57528) | 57528..57737 | + | 210 | WP_244758396.1 | HEAT repeat domain-containing protein | - |
| MT485_RS24985 (57809) | 57809..58459 | - | 651 | WP_001178506.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| MT485_RS24990 (58533) | 58533..60701 | - | 2169 | WP_021537350.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | dfrA12 / sul2 | - | 1..101193 | 101193 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T240884 WP_001331364.1 NZ_CP094989:55826-55978 [Shigella flexneri]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T240884 NZ_LT838200:c4081289-4081002 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 58 bp
>AT240884 NZ_CP094989:c55771-55714 [Shigella flexneri]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
