Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-couple_hipB |
Location | 668264..668912 | Replicon | chromosome |
Accession | NZ_CP094945 | ||
Organism | Streptococcus thermophilus strain VHProbi R08 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | MUB28_RS03550 | Protein ID | WP_014727406.1 |
Coordinates | 668264..668629 (+) | Length | 122 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | J7TXL7 |
Locus tag | MUB28_RS03555 | Protein ID | WP_002890617.1 |
Coordinates | 668619..668912 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MUB28_RS03535 (MUB28_03535) | 664771..665916 | + | 1146 | WP_014727403.1 | AbiH family protein | - |
MUB28_RS03540 (MUB28_03540) | 666078..666797 | + | 720 | WP_014727404.1 | hypothetical protein | - |
MUB28_RS03545 (MUB28_03545) | 666849..668099 | + | 1251 | WP_014727405.1 | restriction endonuclease subunit S | - |
MUB28_RS03550 (MUB28_03550) | 668264..668629 | + | 366 | WP_014727406.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MUB28_RS03555 (MUB28_03555) | 668619..668912 | + | 294 | WP_002890617.1 | helix-turn-helix transcriptional regulator | Antitoxin |
MUB28_RS03560 (MUB28_03560) | 668934..670535 | + | 1602 | WP_041829288.1 | type I restriction-modification system subunit M | - |
MUB28_RS03565 (MUB28_03565) | 670613..671032 | + | 420 | Protein_659 | PD-(D/E)XK nuclease family transposase | - |
MUB28_RS09590 | 671133..672133 | + | 1001 | Protein_660 | DNA/RNA non-specific endonuclease | - |
MUB28_RS03580 (MUB28_03580) | 672283..672843 | + | 561 | WP_014621411.1 | LemA family protein | - |
MUB28_RS03585 (MUB28_03585) | 672845..673744 | + | 900 | WP_014621412.1 | zinc metalloprotease HtpX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 660731..668912 | 8181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 122 a.a. Molecular weight: 14511.65 Da Isoelectric Point: 9.3397
>T240845 WP_014727406.1 NZ_CP094945:668264-668629 [Streptococcus thermophilus]
VHAIYFYKDKQGNQPVLDYMRELARHDSKDSRIKLNKLNDYIELLSQHGTCAGQPYIKHLDAEIWELRPLRDRILFVAWL
DGSFVLLHHFVKKTQKTPRREIEKAKRELQDLKERGLRDEE
VHAIYFYKDKQGNQPVLDYMRELARHDSKDSRIKLNKLNDYIELLSQHGTCAGQPYIKHLDAEIWELRPLRDRILFVAWL
DGSFVLLHHFVKKTQKTPRREIEKAKRELQDLKERGLRDEE
Download Length: 366 bp
>T240845 NZ_LT838196:658135-658449 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10778.52 Da Isoelectric Point: 5.8962
>AT240845 WP_002890617.1 NZ_CP094945:668619-668912 [Streptococcus thermophilus]
MKNSAIGSNWKDVRAELFTKEEILESDLRVAIMTELIEARHEKGFSQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKL
MKNSAIGSNWKDVRAELFTKEEILESDLRVAIMTELIEARHEKGFSQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKL
Download Length: 294 bp
>AT240845 NZ_LT838196:658446-658862 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGCTCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGCTCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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