Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2468697..2469220 Replicon chromosome
Accession NZ_CP094928
Organism Staphylococcus aureus strain 8

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MUO44_RS12200 Protein ID WP_000074048.1
Coordinates 2468697..2468963 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MUO44_RS12205 Protein ID WP_000587616.1
Coordinates 2468963..2469220 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO44_RS12180 (MUO44_12180) 2464003..2465190 - 1188 WP_000026194.1 MFS transporter -
MUO44_RS12185 (MUO44_12185) 2465586..2466362 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
MUO44_RS12190 (MUO44_12190) 2466355..2467017 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
MUO44_RS12195 (MUO44_12195) 2467265..2468341 - 1077 WP_001076671.1 M42 family metallopeptidase -
MUO44_RS12200 (MUO44_12200) 2468697..2468963 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MUO44_RS12205 (MUO44_12205) 2468963..2469220 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUO44_RS12210 (MUO44_12210) 2469579..2470034 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MUO44_RS12215 (MUO44_12215) 2470202..2471779 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
MUO44_RS12220 (MUO44_12220) 2471975..2472724 + 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240801 WP_000074048.1 NZ_CP094928:c2468963-2468697 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240801 NZ_LT795502:902983-903390 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT240801 WP_000587616.1 NZ_CP094928:c2469220-2468963 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240801 NZ_LT795502:902736-903002 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References