Detailed information of TA system TA240799

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2437507..2437691
• Replicon: chromosome
• Accession: NZ_CP094928
• Organism: Staphylococcus aureus strain 8

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUO44_RS12060
• Protein ID: WP_000482647.1
• Coordinates: 2437584..2437691 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2437507..2437567 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO44_RS12045 (MUO44_12045)	2432981..2433148	-	168	WP_001790576.1	hypothetical protein	-
MUO44_RS12050 (MUO44_12050)	2433379..2435112	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MUO44_RS12055 (MUO44_12055)	2435137..2436900	-	1764	WP_001064816.1	ABC transporter ATP-binding protein	-
-	2437507..2437567	+	61	-	-	Antitoxin
MUO44_RS12060 (MUO44_12060)	2437584..2437691	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUO44_RS12065 (MUO44_12065)	2437825..2438211	-	387	WP_000779360.1	flippase GtxA	-
MUO44_RS12070 (MUO44_12070)	2438469..2439611	+	1143	WP_001176871.1	glycerate kinase	-
MUO44_RS12075 (MUO44_12075)	2439671..2440330	+	660	WP_000831301.1	membrane protein	-
MUO44_RS12080 (MUO44_12080)	2440512..2441723	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MUO44_RS12085 (MUO44_12085)	2441846..2442319	-	474	WP_000456497.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240799 WP_000482647.1 NZ_CP094928:c2437691-2437584 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240799 NZ_LT795502:c374936-374451 [Escherichia coli]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCGCGTGTTTACGTTATCTGTATTGCCAATACTCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCTTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240799 NZ_CP094928:2437507-2437567 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin