Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-sprA1AS/-
Location 2158950..2159147 Replicon chromosome
Accession NZ_CP094928
Organism Staphylococcus aureus strain 8

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag MUO44_RS10610 Protein ID WP_001802298.1
Coordinates 2159043..2159147 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2158950..2158988 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO44_RS10585 (MUO44_10585) 2155134..2155799 - 666 WP_001024095.1 SDR family oxidoreductase -
MUO44_RS10590 (MUO44_10590) 2155951..2156271 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
MUO44_RS10595 (MUO44_10595) 2156273..2157253 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
MUO44_RS10600 (MUO44_10600) 2157519..2158610 + 1092 WP_000495683.1 hypothetical protein -
MUO44_RS10605 (MUO44_10605) 2158930..2159004 + 75 Protein_2047 hypothetical protein -
- 2158950..2158988 + 39 - - Antitoxin
MUO44_RS10610 (MUO44_10610) 2159043..2159147 - 105 WP_001802298.1 hypothetical protein Toxin
MUO44_RS10615 (MUO44_10615) 2159827..2159985 + 159 WP_001792784.1 hypothetical protein -
MUO44_RS10620 (MUO44_10620) 2160644..2161501 - 858 WP_000370917.1 HAD family hydrolase -
MUO44_RS10625 (MUO44_10625) 2161569..2162353 - 785 Protein_2051 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T240797 WP_001802298.1 NZ_CP094928:c2159147-2159043 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T240797 NZ_LT795502:284928-285203 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 39 bp

>AT240797 NZ_CP094928:2158950-2158988 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References