Detailed information of TA system TA240792

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1851458..1851640
• Replicon: chromosome
• Accession: NZ_CP094928
• Organism: Staphylococcus aureus strain 8

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUO44_RS08875
• Protein ID: WP_001801861.1
• Coordinates: 1851458..1851553 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1851581..1851640 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO44_RS08840 (MUO44_08840)	1847128..1847754	+	627	WP_000669017.1	hypothetical protein	-
MUO44_RS08845 (MUO44_08845)	1847795..1848136	+	342	WP_000627541.1	DUF3969 family protein	-
MUO44_RS08850 (MUO44_08850)	1848237..1848809	+	573	WP_000414202.1	hypothetical protein	-
MUO44_RS08855 (MUO44_08855)	1849007..1849635	-	629	Protein_1741	ImmA/IrrE family metallo-endopeptidase	-
MUO44_RS08860 (MUO44_08860)	1849938..1850114	-	177	WP_000375477.1	hypothetical protein	-
MUO44_RS08865 (MUO44_08865)	1850125..1850508	-	384	WP_000070811.1	hypothetical protein	-
MUO44_RS08870 (MUO44_08870)	1851112..1851255	-	144	WP_001549059.1	transposase	-
MUO44_RS08875 (MUO44_08875)	1851458..1851553	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1851581..1851640	-	60	-	-	Antitoxin
MUO44_RS08880 (MUO44_08880)	1851676..1851777	+	102	WP_001791893.1	hypothetical protein	-
MUO44_RS08885 (MUO44_08885)	1851755..1851931	-	177	Protein_1747	transposase	-
MUO44_RS08890 (MUO44_08890)	1852125..1852502	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1844570..1884744	40174

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240792 WP_001801861.1 NZ_CP094928:1851458-1851553 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240792 NZ_LT706985:c1640529-1640281 [Propionimicrobium sp. Marseille-P3275]
GTGAGTTGGAGTGTTGAGTCCACTCGAAGGTTTGAGCGGGAATTCAAGAAACTCGATAAATTCACTCAACGTTTAATTAA
AGGGCGGATAGAAAAGAATCTTTCTAACACCCAAAACCCTAGACAGCACGGCAGGGCCCTATCTGCGAACCTGGCGAGCC
TGTGGCGATACCGCGTAGGGGATTATCGAATTATTTGTGAAATCGTTGATGAACGGCTGGTGATTCTGGCTTTAAGCGTT
GGCCATTGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT240792 NZ_CP094928:c1851640-1851581 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin