Detailed information of TA system TA240788

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2855096..2855675
• Replicon: chromosome
• Accession: NZ_CP094927
• Organism: Staphylococcus aureus strain 13

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MUO46_RS14315
• Protein ID: WP_001025401.1
• Coordinates: 2855096..2855341 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2855310..2855675 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO46_RS14275 (MUO46_14235)	2850816..2852021	-	1206	WP_000264741.1	site-specific integrase	-
MUO46_RS14280 (MUO46_14240)	2852147..2852761	+	615	WP_000191466.1	hypothetical protein	-
MUO46_RS14285 (MUO46_14245)	2852758..2852904	-	147	WP_001013104.1	hypothetical protein	-
MUO46_RS14290 (MUO46_14250)	2852995..2853390	-	396	WP_000449655.1	hypothetical protein	-
MUO46_RS14295 (MUO46_14255)	2853419..2853853	-	435	WP_000755719.1	hypothetical protein	-
MUO46_RS14300 (MUO46_14260)	2853871..2854332	-	462	WP_000525004.1	hypothetical protein	-
MUO46_RS14305 (MUO46_14265)	2854345..2854668	-	324	WP_001260485.1	helix-turn-helix transcriptional regulator	-
MUO46_RS14310 (MUO46_14270)	2854832..2855080	+	249	WP_000272860.1	helix-turn-helix transcriptional regulator	-
MUO46_RS14315 (MUO46_14275)	2855096..2855341	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MUO46_RS14320 (MUO46_14280)	2855310..2855675	-	366	WP_001128433.1	hypothetical protein	Antitoxin
MUO46_RS14325 (MUO46_14285)	2855730..2855945	+	216	WP_001036302.1	hypothetical protein	-
MUO46_RS14330 (MUO46_14290)	2855970..2856233	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
MUO46_RS14335 (MUO46_14295)	2856246..2856407	+	162	WP_001285963.1	DUF1270 family protein	-
MUO46_RS14340 (MUO46_14300)	2856486..2856809	+	324	WP_000174994.1	hypothetical protein	-
MUO46_RS14345 (MUO46_14305)	2856824..2857186	+	363	WP_150868153.1	hypothetical protein	-
MUO46_RS14350 (MUO46_14310)	2857183..2858349	+	1167	WP_277445891.1	DUF2800 domain-containing protein	-
MUO46_RS14355 (MUO46_14315)	2858376..2858930	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2850816..2871938	21122

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T240788 WP_001025401.1 NZ_CP094927:2855096-2855341 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T240788 NZ_LT706985:c907015-906728 [Propionimicrobium sp. Marseille-P3275]
ATGGCAGTGACAATTAGCACCTGGGACGCCAGCCAATACCTTGAAACTAAAGATGACATCGTGGCCTACCTTAATGCGGC
GTTTGAAGAGTCAGATCCGGCAATTCTGCAAGCGGCACTTGGTGATGTTGCCAGATCGCGAGGCATGAGCGCTATCGCTA
GGCAGGCGGGAGTGGGGCGCGAGTCTTTGTATAAATCACTATCGCAAGACGGAAACCCATCTTGGCAGACGATTGCGAAA
ATATTCGATGCGCTCGGTCTGCAACTGCAAGTCAAAGTGTCGGCTTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT240788 NZ_CP094927:c2855675-2855310 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin