Detailed information of TA system TA240785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1572764..1573263
• Replicon: chromosome
• Accession: NZ_CP094927
• Organism: Staphylococcus aureus strain 13

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUO46_RS08140
• Protein ID: WP_000074044.1
• Coordinates: 1572764..1573006 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: MUO46_RS08145
• Protein ID: WP_000587618.1
• Coordinates: 1573006..1573263 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO46_RS08120 (MUO46_08090)	1568069..1569256	-	1188	WP_000026189.1	MFS transporter	-
MUO46_RS08125 (MUO46_08095)	1569652..1570428	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
MUO46_RS08130 (MUO46_08100)	1570421..1571083	-	663	WP_000923523.1	ATP-binding cassette domain-containing protein	-
MUO46_RS08135 (MUO46_08105)	1571331..1572407	-	1077	WP_001076672.1	M42 family metallopeptidase	-
MUO46_RS08140 (MUO46_08110)	1572764..1573006	-	243	WP_000074044.1	Txe/YoeB family addiction module toxin	Toxin
MUO46_RS08145 (MUO46_08115)	1573006..1573263	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUO46_RS08150 (MUO46_08120)	1573622..1574077	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
MUO46_RS08155 (MUO46_08125)	1574245..1575822	-	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
MUO46_RS08160 (MUO46_08130)	1576017..1576766	+	750	WP_000072459.1	CPBP family lipoprotein N-acylation protein LnsB	-
MUO46_RS08165 (MUO46_08135)	1576997..1578190	-	1194	WP_000675411.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9649.18 Da
• Isoelectric Point: 10.1469

>T240785 WP_000074044.1 NZ_CP094927:c1573006-1572764 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Nucleotide

• Length: 243 bp

>T240785 NZ_LT706985:114170-114454 [Propionimicrobium sp. Marseille-P3275]
ATGAGGCTGACTAGCGTTTTCCGCACCTACCAGTTCAAGCGCGACGCTAAAGCGCCATTTAAGAAAAACTATGATGCCCA
GAAGTTGGCGTCTGCCGTTGAAGCGTTGCTCGCCCAAGACCGTGATGGTTTGTGTACCCACTATCGCGACCATGCATTGC
AGGGCAGTTGGAAAGGATATCGAGAAATCCACATCGAAGCAGACTGGCTATTGATATACCGCGTAGAGCGTAGCGAGTTG
CTTCTGGTACTTACCCGAACCGGATCTCACGACGACCTGTTCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT240785 WP_000587618.1 NZ_CP094927:c1573263-1573006 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT240785 NZ_LT706985:113920-114183 [Propionimicrobium sp. Marseille-P3275]
ATGATTCTGGTGGCTAACGTATCTTTTCGGACAGACGATGAGACGAAGGCTCAAGCTGCGGAGCTATTCCGTGATCTCGG
TTTGGATATGAGCACTGCCATCAATATGTTCTTGAGGCAGTCGATTGCCAGCAACGGCATTCCGTTTACGCCGCACCGCG
AAAATTTCGCAAGTGCGGTTGCTCGCGCACAAGCCGATTCTCGCACCGGAGCTTCGTTCAATAGCGTTGCTGAGCTAATG
GCGGATCTTAATGAGGCTGACTAG

Structures

Antitoxin

• AlphaFold DB: T1YBB2