Detailed information of TA system TA240783

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1541277..1541461
• Replicon: chromosome
• Accession: NZ_CP094927
• Organism: Staphylococcus aureus strain 13

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUO46_RS08000
• Protein ID: WP_000482647.1
• Coordinates: 1541354..1541461 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1541277..1541337 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO46_RS07985 (MUO46_07955)	1536731..1536898	-	168	WP_001790576.1	hypothetical protein	-
MUO46_RS07990 (MUO46_07960)	1537129..1538862	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MUO46_RS07995 (MUO46_07965)	1538887..1540650	-	1764	WP_001064814.1	ABC transporter ATP-binding protein	-
-	1541277..1541337	+	61	-	-	Antitoxin
MUO46_RS08000 (MUO46_07970)	1541354..1541461	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUO46_RS08005 (MUO46_07975)	1541595..1541981	-	387	WP_000779360.1	flippase GtxA	-
MUO46_RS08010 (MUO46_07980)	1542239..1543381	+	1143	WP_001176863.1	glycerate kinase	-
MUO46_RS08015 (MUO46_07985)	1543441..1544100	+	660	WP_000831298.1	membrane protein	-
MUO46_RS08020 (MUO46_07990)	1544282..1545493	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MUO46_RS08025 (MUO46_07995)	1545616..1546089	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sbi / hlgA / hlgC / hlgB	1474511..1541981	67470

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240783 WP_000482647.1 NZ_CP094927:c1541461-1541354 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240783 NZ_LT703507:95384-95800 [Mycobacterium intracellulare subsp. chimaera]
CTGATCATCGACTCTTCCGCGATCGTCGCCCTCATCCAGGGCGAGGACCCCTACACCGAACAGATCGCGGCCGCCATCGC
CGCCGATCCCAGCCCCGTCATGTCCACGGCCAACGCAGCCGAATGCCTCATCGTTCTCACCAACCGACACGGCGCGACCG
CGCGCACCGTCTTCGACCGCCTACGATCCGAAATCAACCTCGGCTTCCAGCCCTTCACCCTCGAACACGCGATCGCCGCC
CACCGCGCCTACCTCCACTACGGAAAAGGCCGCCACCCCGCCGCCCTCAACTACGGCGACACCATGGCCTACGCCACCGC
CAAACTCGCACACGAACCCCTCATCGCCATCGGCAACGACTTCACCCAAACCGACCTCGAATTCAACGGCGTCATCGGCT
ACTGGCCAGCGCCCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240783 NZ_CP094927:1541277-1541337 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin