Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 1471157..1471674 | Replicon | chromosome |
| Accession | NZ_CP094927 | ||
| Organism | Staphylococcus aureus strain 13 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | MUO46_RS07515 | Protein ID | WP_000113262.1 |
| Coordinates | 1471157..1471423 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MUO46_RS07520 | Protein ID | WP_000584499.1 |
| Coordinates | 1471423..1471674 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO46_RS07485 (MUO46_07455) | 1466578..1467114 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| MUO46_RS07490 (MUO46_07460) | 1467348..1468172 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| MUO46_RS07495 (MUO46_07465) | 1468389..1468571 | - | 183 | WP_000079142.1 | hypothetical protein | - |
| MUO46_RS07500 (MUO46_07470) | 1468658..1469125 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| MUO46_RS07505 (MUO46_07475) | 1469311..1470861 | - | 1551 | WP_000727763.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MUO46_RS07510 (MUO46_07480) | 1471045..1471122 | - | 78 | Protein_1444 | hypothetical protein | - |
| MUO46_RS07515 (MUO46_07485) | 1471157..1471423 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUO46_RS07520 (MUO46_07490) | 1471423..1471674 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUO46_RS07525 (MUO46_07495) | 1471839..1471940 | - | 102 | WP_031774922.1 | hypothetical protein | - |
| MUO46_RS07530 (MUO46_07500) | 1471947..1472546 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| MUO46_RS07535 (MUO46_07505) | 1472565..1472927 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MUO46_RS07540 (MUO46_07510) | 1473182..1474432 | + | 1251 | WP_001012223.1 | FemA/FemB family glycyltransferase FmhA | - |
| MUO46_RS07545 (MUO46_07515) | 1474511..1475830 | - | 1320 | WP_001808146.1 | ISL3-like element IS1181 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1474511..1475830 | 1319 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T240781 WP_000113262.1 NZ_CP094927:c1471423-1471157 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T240781 NZ_LT703507:c10860-10567 [Mycobacterium intracellulare subsp. chimaera]
GTGAGCGCATACGTCCTTTCACCCGCTGCGCAAGCAGATTTGGAACAGATCTGGGACTACACGCACGAGCACTGGGGCCT
GGATCAGGCTGAGCAGTACCTGCGAGAACTTCAACGCGCTATCGAGCGCGCAGCGGCGAACCCCCGGATCGGGCGGGCCT
GCGACGAGATCCGCCCGGGCTATCGCAAGCTGGCAGCCGGGTCGCACATGCTGTTTTATCGGGTGACAACCCAAGGCTTC
CTCGATGTCGTGCGTGTCCTGCACCAACGCATGGACGTCGACCGCCACCTTTGA
GTGAGCGCATACGTCCTTTCACCCGCTGCGCAAGCAGATTTGGAACAGATCTGGGACTACACGCACGAGCACTGGGGCCT
GGATCAGGCTGAGCAGTACCTGCGAGAACTTCAACGCGCTATCGAGCGCGCAGCGGCGAACCCCCGGATCGGGCGGGCCT
GCGACGAGATCCGCCCGGGCTATCGCAAGCTGGCAGCCGGGTCGCACATGCTGTTTTATCGGGTGACAACCCAAGGCTTC
CTCGATGTCGTGCGTGTCCTGCACCAACGCATGGACGTCGACCGCCACCTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT240781 WP_000584499.1 NZ_CP094927:c1471674-1471423 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT240781 NZ_LT703507:c11108-10857 [Mycobacterium intracellulare subsp. chimaera]
GTGGGTAAAAACACGTCCTTCAGTCTCGATGAGCATTACAGCGCCTTCATTGAGGCTGAGGTGGCTGCGGGACGTTACCG
GTCGGCCAGTGATGTCGTGCGCTCCGCGTTGCGGTTACTCGAGGACCGTGAAATTCAGCTTCGGGCACTGCGCGAGGCGC
TAGTGGCCGGTGAGCGCAGCGGCACTTCAACACCGTTTGACTTCGACGCCTTCCTCGACGGCAAACGCGCCGAAAAGCCG
CAAGGCCGGTGA
GTGGGTAAAAACACGTCCTTCAGTCTCGATGAGCATTACAGCGCCTTCATTGAGGCTGAGGTGGCTGCGGGACGTTACCG
GTCGGCCAGTGATGTCGTGCGCTCCGCGTTGCGGTTACTCGAGGACCGTGAAATTCAGCTTCGGGCACTGCGCGAGGCGC
TAGTGGCCGGTGAGCGCAGCGGCACTTCAACACCGTTTGACTTCGACGCCTTCCTCGACGGCAAACGCGCCGAAAAGCCG
CAAGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|