Detailed information of TA system TA240775

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2839389..2839968
• Replicon: chromosome
• Accession: NZ_CP094926
• Organism: Staphylococcus aureus strain 14

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MUO45_RS14200
• Protein ID: WP_001025401.1
• Coordinates: 2839389..2839634 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2839603..2839968 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO45_RS14160 (MUO45_14125)	2835109..2836314	-	1206	WP_000264741.1	site-specific integrase	-
MUO45_RS14165 (MUO45_14130)	2836440..2837054	+	615	WP_000191466.1	hypothetical protein	-
MUO45_RS14170 (MUO45_14135)	2837051..2837197	-	147	WP_001013104.1	hypothetical protein	-
MUO45_RS14175 (MUO45_14140)	2837288..2837683	-	396	WP_000449655.1	hypothetical protein	-
MUO45_RS14180 (MUO45_14145)	2837712..2838146	-	435	WP_000755719.1	hypothetical protein	-
MUO45_RS14185 (MUO45_14150)	2838164..2838625	-	462	WP_000525004.1	hypothetical protein	-
MUO45_RS14190 (MUO45_14155)	2838638..2838961	-	324	WP_001260485.1	helix-turn-helix transcriptional regulator	-
MUO45_RS14195 (MUO45_14160)	2839125..2839373	+	249	WP_000272860.1	helix-turn-helix transcriptional regulator	-
MUO45_RS14200 (MUO45_14165)	2839389..2839634	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MUO45_RS14205 (MUO45_14170)	2839603..2839968	-	366	WP_001128433.1	hypothetical protein	Antitoxin
MUO45_RS14210 (MUO45_14175)	2840023..2840238	+	216	WP_001036302.1	hypothetical protein	-
MUO45_RS14215 (MUO45_14180)	2840263..2840526	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
MUO45_RS14220 (MUO45_14185)	2840539..2840700	+	162	WP_001285963.1	DUF1270 family protein	-
MUO45_RS14225 (MUO45_14190)	2840779..2841102	+	324	WP_000174994.1	hypothetical protein	-
MUO45_RS14230 (MUO45_14195)	2841117..2841479	+	363	WP_150868153.1	hypothetical protein	-
MUO45_RS14235 (MUO45_14200)	2841476..2842642	+	1167	WP_277445891.1	DUF2800 domain-containing protein	-
MUO45_RS14240 (MUO45_14205)	2842669..2843223	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2835109..2856231	21122

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T240775 WP_001025401.1 NZ_CP094926:2839389-2839634 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T240775 NZ_LT703505:1503364-1503732 [Mycobacterium intracellulare subsp. chimaera]
ATGATCCTCGTCGACACCGCGGTGTGGATCGATCATCTACACACCGCGGAGTTGCGGCTAGTCAAGCTGCTGGAGATCGA
CCAAGTTGGCTGTCATGCGCTGGTCATCGAAGAGCTGGCGCTGGGGTCGATCTCGCGACGTGAGGTGGTGCTCGACCTCC
TCGCGAATCTTCGCCAGTTTCCGACCGTCCAGCACGCCGAGATCCTTCACCTCACCGGTCAACGCAAACTGTATGGACGC
GGTCTCAGTGCGGTCGACGTCCATCTCATGGCCGCCGTCGCCCTGGTTGAAGGCGCGCAGCTGTGGACGAGAGACAAGCG
GTTGAAGGCTGCGTCGGTCGATGCGGGCATCGCACTCTTCGATGCCTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT240775 NZ_CP094926:c2839968-2839603 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin