Detailed information of TA system TA240772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1556650..1557149
• Replicon: chromosome
• Accession: NZ_CP094926
• Organism: Staphylococcus aureus strain 14

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUO45_RS08015
• Protein ID: WP_000074044.1
• Coordinates: 1556650..1556892 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: MUO45_RS08020
• Protein ID: WP_000587618.1
• Coordinates: 1556892..1557149 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO45_RS07995 (MUO45_07970)	1551955..1553142	-	1188	WP_000026189.1	MFS transporter	-
MUO45_RS08000 (MUO45_07975)	1553538..1554314	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
MUO45_RS08005 (MUO45_07980)	1554307..1554969	-	663	WP_000923523.1	ATP-binding cassette domain-containing protein	-
MUO45_RS08010 (MUO45_07985)	1555217..1556293	-	1077	WP_001076672.1	M42 family metallopeptidase	-
MUO45_RS08015 (MUO45_07990)	1556650..1556892	-	243	WP_000074044.1	Txe/YoeB family addiction module toxin	Toxin
MUO45_RS08020 (MUO45_07995)	1556892..1557149	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUO45_RS08025 (MUO45_08000)	1557234..1557449	-	216	WP_031797608.1	hypothetical protein	-
MUO45_RS08030 (MUO45_08005)	1557508..1557963	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
MUO45_RS08035 (MUO45_08010)	1558131..1559708	-	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
MUO45_RS08040 (MUO45_08015)	1559903..1560652	+	750	WP_000072459.1	CPBP family lipoprotein N-acylation protein LnsB	-
MUO45_RS08045 (MUO45_08020)	1560883..1562076	-	1194	WP_000675411.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9649.18 Da
• Isoelectric Point: 10.1469

>T240772 WP_000074044.1 NZ_CP094926:c1556892-1556650 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Nucleotide

• Length: 243 bp

>T240772 NZ_LT703505:c1038614-1038207 [Mycobacterium intracellulare subsp. chimaera]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT240772 WP_000587618.1 NZ_CP094926:c1557149-1556892 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT240772 NZ_LT703505:c1038890-1038618 [Mycobacterium intracellulare subsp. chimaera]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Structures

Antitoxin

• AlphaFold DB: T1YBB2