Detailed information of TA system TA240770

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1525163..1525347
• Replicon: chromosome
• Accession: NZ_CP094926
• Organism: Staphylococcus aureus strain 14

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUO45_RS07875
• Protein ID: WP_000482647.1
• Coordinates: 1525240..1525347 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1525163..1525223 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO45_RS07860 (MUO45_07835)	1520617..1520784	-	168	WP_001790576.1	hypothetical protein	-
MUO45_RS07865 (MUO45_07840)	1521015..1522748	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MUO45_RS07870 (MUO45_07845)	1522773..1524536	-	1764	WP_001064814.1	ABC transporter ATP-binding protein	-
-	1525163..1525223	+	61	-	-	Antitoxin
MUO45_RS07875 (MUO45_07850)	1525240..1525347	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUO45_RS07880 (MUO45_07855)	1525481..1525867	-	387	WP_000779360.1	flippase GtxA	-
MUO45_RS07885 (MUO45_07860)	1526125..1527267	+	1143	WP_001176863.1	glycerate kinase	-
MUO45_RS07890 (MUO45_07865)	1527327..1527986	+	660	WP_000831298.1	membrane protein	-
MUO45_RS07895 (MUO45_07870)	1528168..1529379	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MUO45_RS07900 (MUO45_07875)	1529502..1529975	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sbi / hlgA / hlgC / hlgB	1466769..1527986	61217

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240770 WP_000482647.1 NZ_CP094926:c1525347-1525240 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240770 NZ_LT703505:c864586-864281 [Mycobacterium intracellulare subsp. chimaera]
GTGATCACACCCGGAGACATCACGCCAGGCCGCGACACCAACCAGGAACTGTACGTTGTCGTACTATCTAACACGATTCA
CCTCGCAGCCGCCACCGGCCAGGTGATCATCTGCCCCTTCATTCCCGGTGAAATCCCCAGCAGCACAATGGCTATGATCG
TCACAGTGCTGCAACCCAAAGGGGTTGTCTTACCGGAGCTCATCCAGTGGCTTCCTGTCGCGGCCCTCGACCAACCCATC
GGCAATATCGGCGGCATCGCGCTCGCTGACACGACCACGACCGCCGTCACCGCGCTCATTTCCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240770 NZ_CP094926:1525163-1525223 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin