Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 1455043..1455560 | Replicon | chromosome |
| Accession | NZ_CP094926 | ||
| Organism | Staphylococcus aureus strain 14 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | MUO45_RS07390 | Protein ID | WP_000113262.1 |
| Coordinates | 1455043..1455309 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MUO45_RS07395 | Protein ID | WP_000584499.1 |
| Coordinates | 1455309..1455560 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO45_RS07360 (MUO45_07335) | 1450464..1451000 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| MUO45_RS07365 (MUO45_07340) | 1451234..1452058 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| MUO45_RS07370 (MUO45_07345) | 1452275..1452457 | - | 183 | WP_000079142.1 | hypothetical protein | - |
| MUO45_RS07375 (MUO45_07350) | 1452544..1453011 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| MUO45_RS07380 (MUO45_07355) | 1453197..1454747 | - | 1551 | WP_000727763.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MUO45_RS07385 (MUO45_07360) | 1454931..1455008 | - | 78 | Protein_1419 | hypothetical protein | - |
| MUO45_RS07390 (MUO45_07365) | 1455043..1455309 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUO45_RS07395 (MUO45_07370) | 1455309..1455560 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUO45_RS07400 (MUO45_07375) | 1455725..1455826 | - | 102 | WP_031774922.1 | hypothetical protein | - |
| MUO45_RS07405 (MUO45_07380) | 1455833..1456432 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| MUO45_RS07410 (MUO45_07385) | 1456451..1456813 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MUO45_RS07415 (MUO45_07390) | 1457068..1458318 | + | 1251 | WP_001012223.1 | FemA/FemB family glycyltransferase FmhA | - |
| MUO45_RS07420 (MUO45_07395) | 1458397..1459716 | - | 1320 | WP_001808146.1 | ISL3-like element IS1181 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1458397..1459716 | 1319 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T240768 WP_000113262.1 NZ_CP094926:c1455309-1455043 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T240768 NZ_LT673656:c5257777-5257499 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT240768 WP_000584499.1 NZ_CP094926:c1455560-1455309 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT240768 NZ_LT673656:c5257487-5257182 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|