Detailed information of TA system TA240762

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2839397..2839976
• Replicon: chromosome
• Accession: NZ_CP094925
• Organism: Staphylococcus aureus strain 15

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MUO48_RS14145
• Protein ID: WP_001025401.1
• Coordinates: 2839397..2839642 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2839611..2839976 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO48_RS14105 (MUO48_14095)	2835118..2836323	-	1206	WP_000264741.1	site-specific integrase	-
MUO48_RS14110 (MUO48_14100)	2836449..2837063	+	615	WP_000191466.1	hypothetical protein	-
MUO48_RS14115 (MUO48_14105)	2837060..2837206	-	147	WP_001013104.1	hypothetical protein	-
MUO48_RS14120 (MUO48_14110)	2837296..2837691	-	396	WP_000449655.1	hypothetical protein	-
MUO48_RS14125 (MUO48_14115)	2837720..2838154	-	435	WP_000755719.1	hypothetical protein	-
MUO48_RS14130 (MUO48_14120)	2838172..2838633	-	462	WP_000525004.1	hypothetical protein	-
MUO48_RS14135 (MUO48_14125)	2838646..2838969	-	324	WP_001260485.1	helix-turn-helix transcriptional regulator	-
MUO48_RS14140 (MUO48_14130)	2839133..2839381	+	249	WP_000272860.1	helix-turn-helix transcriptional regulator	-
MUO48_RS14145 (MUO48_14135)	2839397..2839642	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MUO48_RS14150 (MUO48_14140)	2839611..2839976	-	366	WP_001128433.1	hypothetical protein	Antitoxin
MUO48_RS14155 (MUO48_14145)	2840031..2840246	+	216	WP_001036302.1	hypothetical protein	-
MUO48_RS14160 (MUO48_14150)	2840271..2840534	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
MUO48_RS14165 (MUO48_14155)	2840547..2840708	+	162	WP_001285963.1	DUF1270 family protein	-
MUO48_RS14170 (MUO48_14160)	2840787..2841110	+	324	WP_000174994.1	hypothetical protein	-
MUO48_RS14175 (MUO48_14165)	2841125..2841487	+	363	WP_150868153.1	hypothetical protein	-
MUO48_RS14180 (MUO48_14170)	2841484..2842650	+	1167	WP_277445891.1	DUF2800 domain-containing protein	-
MUO48_RS14185 (MUO48_14175)	2842677..2843231	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2835118..2856239	21121

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T240762 WP_001025401.1 NZ_CP094925:2839397-2839642 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T240762 NZ_LT671859:c2476856-2476749 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT240762 NZ_CP094925:c2839976-2839611 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin