Detailed information of TA system TA240759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1556237..1556736
• Replicon: chromosome
• Accession: NZ_CP094925
• Organism: Staphylococcus aureus strain 15

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUO48_RS07980
• Protein ID: WP_000074044.1
• Coordinates: 1556237..1556479 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: MUO48_RS07985
• Protein ID: WP_000587618.1
• Coordinates: 1556479..1556736 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO48_RS07960 (MUO48_07955)	1551542..1552729	-	1188	WP_000026189.1	MFS transporter	-
MUO48_RS07965 (MUO48_07960)	1553125..1553901	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
MUO48_RS07970 (MUO48_07965)	1553894..1554556	-	663	WP_000923523.1	ATP-binding cassette domain-containing protein	-
MUO48_RS07975 (MUO48_07970)	1554804..1555880	-	1077	WP_001076672.1	M42 family metallopeptidase	-
MUO48_RS07980 (MUO48_07975)	1556237..1556479	-	243	WP_000074044.1	Txe/YoeB family addiction module toxin	Toxin
MUO48_RS07985 (MUO48_07980)	1556479..1556736	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUO48_RS07990 (MUO48_07985)	1557095..1557550	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
MUO48_RS07995 (MUO48_07990)	1557718..1559295	-	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
MUO48_RS08000 (MUO48_07995)	1559490..1560239	+	750	WP_000072459.1	CPBP family lipoprotein N-acylation protein LnsB	-
MUO48_RS08005 (MUO48_08000)	1560470..1561663	-	1194	WP_000675411.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9649.18 Da
• Isoelectric Point: 10.1469

>T240759 WP_000074044.1 NZ_CP094925:c1556479-1556237 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Nucleotide

• Length: 243 bp

>T240759 NZ_LT671859:c2129224-2129015 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT240759 WP_000587618.1 NZ_CP094925:c1556736-1556479 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT240759 NZ_LT671859:c2129529-2129236 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2