Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1524750..1524934 Replicon chromosome
Accession NZ_CP094925
Organism Staphylococcus aureus strain 15

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUO48_RS07840 Protein ID WP_000482647.1
Coordinates 1524827..1524934 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1524750..1524810 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO48_RS07825 (MUO48_07820) 1520204..1520371 - 168 WP_001790576.1 hypothetical protein -
MUO48_RS07830 (MUO48_07825) 1520602..1522335 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
MUO48_RS07835 (MUO48_07830) 1522360..1524123 - 1764 WP_001064814.1 ABC transporter ATP-binding protein -
- 1524750..1524810 + 61 - - Antitoxin
MUO48_RS07840 (MUO48_07835) 1524827..1524934 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUO48_RS07845 (MUO48_07840) 1525068..1525454 - 387 WP_000779360.1 flippase GtxA -
MUO48_RS07850 (MUO48_07845) 1525712..1526854 + 1143 WP_001176863.1 glycerate kinase -
MUO48_RS07855 (MUO48_07850) 1526914..1527573 + 660 WP_000831298.1 membrane protein -
MUO48_RS07860 (MUO48_07855) 1527755..1528966 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MUO48_RS07865 (MUO48_07860) 1529089..1529562 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sbi / hlgA / hlgC / hlgB 1466356..1525454 59098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T240757 WP_000482647.1 NZ_CP094925:c1524934-1524827 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240757 NZ_LT671859:c2009342-2009166 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 61 bp

>AT240757 NZ_CP094925:1524750-1524810 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References