Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1454644..1455161 Replicon chromosome
Accession NZ_CP094925
Organism Staphylococcus aureus strain 15

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag MUO48_RS07355 Protein ID WP_000113262.1
Coordinates 1454644..1454910 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUO48_RS07360 Protein ID WP_000584499.1
Coordinates 1454910..1455161 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO48_RS07325 (MUO48_07320) 1450065..1450601 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MUO48_RS07330 (MUO48_07325) 1450835..1451659 - 825 WP_000572040.1 formate/nitrite transporter family protein -
MUO48_RS07335 (MUO48_07330) 1451876..1452058 - 183 WP_000079142.1 hypothetical protein -
MUO48_RS07340 (MUO48_07335) 1452145..1452612 - 468 WP_000153344.1 SRPBCC domain-containing protein -
MUO48_RS07345 (MUO48_07340) 1452798..1454348 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUO48_RS07350 (MUO48_07345) 1454532..1454609 - 78 Protein_1412 hypothetical protein -
MUO48_RS07355 (MUO48_07350) 1454644..1454910 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
MUO48_RS07360 (MUO48_07355) 1454910..1455161 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUO48_RS07365 (MUO48_07360) 1455326..1455427 - 102 WP_031774922.1 hypothetical protein -
MUO48_RS07370 (MUO48_07365) 1455434..1456033 - 600 WP_000162813.1 DsbA family protein -
MUO48_RS07375 (MUO48_07370) 1456052..1456414 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUO48_RS07380 (MUO48_07375) 1456669..1457919 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
MUO48_RS07385 (MUO48_07380) 1457998..1459317 - 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1457998..1459317 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T240755 WP_000113262.1 NZ_CP094925:c1454910-1454644 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240755 NZ_LT671859:1848827-1848922 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240755 WP_000584499.1 NZ_CP094925:c1455161-1454910 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240755 NZ_LT671859:c1849009-1848950 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References