Detailed information of TA system TA240749

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2853834..2854413
• Replicon: chromosome
• Accession: NZ_CP094924
• Organism: Staphylococcus aureus strain 18

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MUO49_RS14250
• Protein ID: WP_001025401.1
• Coordinates: 2853834..2854079 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2854048..2854413 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO49_RS14210 (MUO49_14195)	2849554..2850759	-	1206	WP_000264741.1	site-specific integrase	-
MUO49_RS14215 (MUO49_14200)	2850885..2851499	+	615	WP_000191466.1	hypothetical protein	-
MUO49_RS14220 (MUO49_14205)	2851496..2851642	-	147	WP_001013104.1	hypothetical protein	-
MUO49_RS14225 (MUO49_14210)	2851733..2852128	-	396	WP_000449655.1	hypothetical protein	-
MUO49_RS14230 (MUO49_14215)	2852157..2852591	-	435	WP_000755719.1	hypothetical protein	-
MUO49_RS14235 (MUO49_14220)	2852609..2853070	-	462	WP_000525004.1	hypothetical protein	-
MUO49_RS14240 (MUO49_14225)	2853083..2853406	-	324	WP_277558125.1	helix-turn-helix transcriptional regulator	-
MUO49_RS14245 (MUO49_14230)	2853570..2853818	+	249	WP_000272860.1	helix-turn-helix transcriptional regulator	-
MUO49_RS14250 (MUO49_14235)	2853834..2854079	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MUO49_RS14255 (MUO49_14240)	2854048..2854413	-	366	WP_001128433.1	hypothetical protein	Antitoxin
MUO49_RS14260 (MUO49_14245)	2854468..2854683	+	216	WP_001036302.1	hypothetical protein	-
MUO49_RS14265 (MUO49_14250)	2854708..2854971	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
MUO49_RS14270 (MUO49_14255)	2854984..2855145	+	162	WP_001285963.1	DUF1270 family protein	-
MUO49_RS14275 (MUO49_14260)	2855224..2855547	+	324	WP_000174994.1	hypothetical protein	-
MUO49_RS14280 (MUO49_14265)	2855562..2855924	+	363	WP_150868153.1	hypothetical protein	-
MUO49_RS14285 (MUO49_14270)	2855921..2857087	+	1167	WP_277445891.1	DUF2800 domain-containing protein	-
MUO49_RS14290 (MUO49_14275)	2857114..2857668	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2849554..2870676	21122

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T240749 WP_001025401.1 NZ_CP094924:2853834-2854079 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T240749 NZ_LT635457:1267677-1267940 [Actinomyces pacaensis]
ATGAAGACCATGACCTACAGCGAGTCGCGCGCACGCTACGCCGAGGTCCTCGATCAGGTCGTCAACGACCGCGAGGAAAT
CATCATCACCCGCCAGGGCCACGAAAGCGCCGTCATCATGGCGCTCGACGAGTACGAATCTCTCATGGAAACCGTCTACC
TCATGCAGTCTCCTGCAAATGCCCGTCACCTGCGCGAATCGATCGCGCGTCACCGCGCTGGTGAGGGTGTCGTCCATGAC
CTCGTTGAGCCCGACGAGGACTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT240749 NZ_CP094924:c2854413-2854048 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin