Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1570798..1571297 Replicon chromosome
Accession NZ_CP094924
Organism Staphylococcus aureus strain 18

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUO49_RS08080 Protein ID WP_000074044.1
Coordinates 1570798..1571040 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag MUO49_RS08085 Protein ID WP_000587618.1
Coordinates 1571040..1571297 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO49_RS08060 (MUO49_08050) 1566103..1567290 - 1188 WP_000026189.1 MFS transporter -
MUO49_RS08065 (MUO49_08055) 1567686..1568462 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
MUO49_RS08070 (MUO49_08060) 1568455..1569117 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
MUO49_RS08075 (MUO49_08065) 1569365..1570441 - 1077 WP_001076672.1 M42 family metallopeptidase -
MUO49_RS08080 (MUO49_08070) 1570798..1571040 - 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
MUO49_RS08085 (MUO49_08075) 1571040..1571297 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUO49_RS08090 (MUO49_08080) 1571656..1572111 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MUO49_RS08095 (MUO49_08085) 1572279..1573856 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
MUO49_RS08100 (MUO49_08090) 1574051..1574800 + 750 WP_000072459.1 CPBP family lipoprotein N-acylation protein LnsB -
MUO49_RS08105 (MUO49_08095) 1575031..1576224 - 1194 WP_000675411.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T240746 WP_000074044.1 NZ_CP094924:c1571040-1570798 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp

>T240746 NZ_LT632616:c2372324-2371392 [Legionella pneumophila]
ATGAATAAACAGTCACCATATTATAAACAGGTTTTGTTGCTCATTCGTTTAATTCCACTCGTCGAAAAGGAAACTTGTTT
TGCTTTAAAGGGAGGTACTGCCATTAATTTATTTGTGCGAGATTTCCCGAGGTTATCTGTGGATATAGATCTAGCGTATT
TACCCCTCGAGCCACGTGAGATTGCTTTAGCCAATGTGCGTAATGCATTAGCGGGTATTGCGGCAAATATTAATAAAATT
CCAGATTTGAATGCAGTTTTGCAAGATAACAAACCAGATGAAATGCGAATTATTGTTGAAGATCATTCTTCTCTAAATAG
GGGGACCCAAATCAAGATAGAAGTTTCACCTGTTGCGCGTGGAACTCTTTTGCCGCCAGTTGAGCTTGATGTTGTTGCTT
CGGTGGAAAATGAGTTTGGTTTTGCGTCAATGAAAGTCGTTTCTTTGCCTGATCTCTATGGTGGTAAATTATGCGCTGCT
TTAGATCGCCAGCATCCTAGAGATCTTTTTGATGTTAAGGTTTTGTTAGAAAATCAAAAGATTGACCGAGAGCTTTTTAA
TGGGTTTCTTACTTATCTTTTAAGTCACAAAAGGCCTATTTCAGAAATAATGAATCCACGATGGAAAGATATAACTCAAG
TTTTTGAACGTGAATTTAAAGGAATGACTGCTGAACCAGTTACCCTGGAAGAGCTAACAGCAATACCAGGAAAAATGATT
CAGGGTCTTAAAGATAATTTTACTCAGCAGGATTATGATTTTTTAGTCTCTTTTAAAAGGGGCGAGCCTGAGTGGTCTCT
TGCATGTAGCGATCAGATTCAATATCTCCCAGCAGTACAATGGAAGCTTTTAAATATTCGCAAAATGCCCAAACAAAAAC
TCATGGATTCAGTTAGCTTGCTACAAAGAACGATGGGACATTGGCTTAATTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT240746 WP_000587618.1 NZ_CP094924:c1571297-1571040 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240746 NZ_LT632616:c2373113-2372328 [Legionella pneumophila]
ATGTCATCAAAAATAAACTGGCTTCTGAATAATATTGCCTCAGGTGAAATCTTGCTCCAGTCTTGGTTATCAAGCCATGG
AATTACTCCACAATTAGCAAGAAAATATTGTCAAAGCCAGTGGTTGGTAAAATTGGGGGTAGGGGTTTATTATCGTGCAG
GGCGTAAACCTAGATGGCAAAATGCAGTTTATTGTCTTCAGAATCAGAGTCGGTACATGATTCATCTTGCTGGTTTAACC
AGTTTGGCTCAGCAGGGCAAATCGCATTACCTACAGTTTGCACCAGACTCTATTTGGATAAACGTTCAAGCAAAAACGAT
TTTACCAAAGTGGTTTAAAAATTTTCCAGAATTAGTTATTTCTGATGAACTAATACCAAATTGGGAAATCATTAAAACAT
CCAAGTTAAATGCTCAGGATGAGAATGACTTAACTACTATAGAAGTAGATGGGATTAAGTTAAAAGCAAGTAATCAAGAG
TTAGCCGCATTCGAGGTGCTGGAGGCTGTACCTTCCACTTTGTCATTTGAGCATGCAGCAGAGCTTTTTCAAGGATTGGT
AAACTTAAGTCCACGAAAAGTAGAACATATTTTAAAAAGAAGCGGATCTATTCAAACGAACCGACTTTTTTTATTTTTGG
GTCATTTCTATAAACATCCATGGGCTGAACGGGTGAATGAGTCCTTAATTAATCTTGGTGCAGGTAAGCGTCAAATAGTC
CCTGATGGAAAATTAGAAAAACAATATCAAATCACCGTTCCAGAACAATTTATAAGTAGCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References