Detailed information of TA system TA240744

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1539311..1539495
• Replicon: chromosome
• Accession: NZ_CP094924
• Organism: Staphylococcus aureus strain 18

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUO49_RS07940
• Protein ID: WP_000482647.1
• Coordinates: 1539388..1539495 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1539311..1539371 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO49_RS07925 (MUO49_07915)	1534765..1534932	-	168	WP_001790576.1	hypothetical protein	-
MUO49_RS07930 (MUO49_07920)	1535163..1536896	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MUO49_RS07935 (MUO49_07925)	1536921..1538684	-	1764	WP_001064814.1	ABC transporter ATP-binding protein	-
-	1539311..1539371	+	61	-	-	Antitoxin
MUO49_RS07940 (MUO49_07930)	1539388..1539495	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUO49_RS07945 (MUO49_07935)	1539629..1540015	-	387	WP_000779360.1	flippase GtxA	-
MUO49_RS07950 (MUO49_07940)	1540273..1541415	+	1143	WP_001176863.1	glycerate kinase	-
MUO49_RS07955 (MUO49_07945)	1541475..1542134	+	660	WP_000831298.1	membrane protein	-
MUO49_RS07960 (MUO49_07950)	1542316..1543527	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MUO49_RS07965 (MUO49_07955)	1543650..1544123	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sbi / hlgA / hlgC / hlgB	1480918..1540015	59097

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240744 WP_000482647.1 NZ_CP094924:c1539495-1539388 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240744 NZ_LT632614:c2767645-2766794 [Legionella pneumophila]
ATGATCAAAAATATTGGTGAGTCCGTACGCTCACGTTTGAAGAATATAGCTGTTAAAGAAGGTTCTGATTTTAATGCGGT
ATTGACTCGTTATGGTCTAGAGCGTTTGTTGTATCGAATTGGAGAATCAGAATATTCTAACCAGTTTTTGTTGAAAGGTG
CCTTACTGTTTAACCTATGGTACGACATGCCCCATCGCCCAACTAAAGATATTGATTTATTGGGATTTGGTGATAACGAT
CTGGCGTATATTAAGCAAACGTTCAGTAAAATTTGCAGCATCTTTGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTTGACACTATCAAAAAAGATGGAGGTTATACTGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAAGCAAAGA
TTAAAATACAAATTGATATAGGTTATGGTGATGCAGTTACGCCTGGGCCAATAGATGCCCATTATCCCGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATCCGTACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTATTGGG
CATGGCGAATGGTCGATTAAAAGACTACTTGGATCTTTATGTATTATTAGGTAATGAACAGATAGATAATCAAATCTTGG
CTAAAGCTATACAAGCCACATTTAATCGTCGAGGTATGGATCTTCCTGAAGCACTGCCTATTGGCCTGACCGATGAGTTT
GCTAACGACCCAAGCAGGGAGTCAATGTGGAAAGCCTTTTTGAGAAAAAATGAACTAGAGCAGAAACCATTAACTGAAGT
CATTGCTGTGATCAGAAATTTGATTCAAGTGCCATATTCTTTGGCAAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240744 NZ_CP094924:1539311-1539371 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin