Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1470857..1471374 Replicon chromosome
Accession NZ_CP094924
Organism Staphylococcus aureus strain 18

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag MUO49_RS07465 Protein ID WP_000113262.1
Coordinates 1470857..1471123 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUO49_RS07470 Protein ID WP_000584499.1
Coordinates 1471123..1471374 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO49_RS07435 (MUO49_07425) 1466278..1466814 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MUO49_RS07440 (MUO49_07430) 1467048..1467872 - 825 WP_000572040.1 formate/nitrite transporter family protein -
MUO49_RS07445 (MUO49_07435) 1468089..1468271 - 183 WP_000079142.1 hypothetical protein -
MUO49_RS07450 (MUO49_07440) 1468358..1468825 - 468 WP_000153344.1 SRPBCC domain-containing protein -
MUO49_RS07455 (MUO49_07445) 1469011..1470561 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUO49_RS07460 (MUO49_07450) 1470745..1470822 - 78 Protein_1434 hypothetical protein -
MUO49_RS07465 (MUO49_07455) 1470857..1471123 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
MUO49_RS07470 (MUO49_07460) 1471123..1471374 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUO49_RS07475 (MUO49_07465) 1471539..1472102 - 564 WP_277558090.1 DsbA family protein -
MUO49_RS07480 (MUO49_07470) 1472121..1472483 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUO49_RS07485 (MUO49_07475) 1472738..1473988 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
MUO49_RS07490 (MUO49_07480) 1474088..1474819 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUO49_RS07495 (MUO49_07485) 1474816..1475535 - 720 WP_000479576.1 amino acid ABC transporter permease -
MUO49_RS07500 (MUO49_07490) 1475516..1476295 - 780 WP_000825921.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T240742 WP_000113262.1 NZ_CP094924:c1471123-1470857 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240742 NZ_LT632614:c68979-67675 [Legionella pneumophila]
ATGGTAATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGAGCTTACCCAGGATAATGCAGGTGGTTTGAG
TTTTTCCTACGTTGCTGACTGGATTTCCAAGCCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAATAAATCAAAGGA
TTTCAGGAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCGAGAATTCAAGCTCGT
TTTCAGGCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCAGTGATTGTGTTGGTGCAATACAAATTGTTGA
ACGTATTCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTT
ACCAAACCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCT
TTTCTATATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATA
TTTACCACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTT
TAGAGGTTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAGGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGT
CGAGATAACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCA
GTCAGATGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGATAGAGATGAAT
TTTTCAGAGCACAGGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAATTTCAGTATAAGTATACAACCA
CAAGGCGGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATCCTATCGTGGAACAAAAACAGCTATCCTTTAA
GAAATTGAAAATGGCAATGGCTTTATATGGTAAAAATAGTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTG
AAACAGCAAAATACGTTCAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCT
ATCGATGAGGTCTCAACACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTT
TAAGGAGCGAATGATATCCACATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240742 WP_000584499.1 NZ_CP094924:c1471374-1471123 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240742 NZ_LT632614:c69212-68973 [Legionella pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCTGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGAGATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References