Detailed information of TA system TA240736

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2854007..2854586
• Replicon: chromosome
• Accession: NZ_CP094923
• Organism: Staphylococcus aureus strain 1824

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MUO47_RS14260
• Protein ID: WP_001025401.1
• Coordinates: 2854007..2854252 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2854221..2854586 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO47_RS14220 (MUO47_14205)	2849728..2850933	-	1206	WP_000264741.1	site-specific integrase	-
MUO47_RS14225 (MUO47_14210)	2851059..2851673	+	615	WP_000191466.1	hypothetical protein	-
MUO47_RS14230 (MUO47_14215)	2851670..2851816	-	147	WP_001013104.1	hypothetical protein	-
MUO47_RS14235 (MUO47_14220)	2851907..2852302	-	396	WP_000449655.1	hypothetical protein	-
MUO47_RS14240 (MUO47_14225)	2852331..2852765	-	435	WP_000755719.1	hypothetical protein	-
MUO47_RS14245 (MUO47_14230)	2852783..2853244	-	462	WP_000525004.1	hypothetical protein	-
MUO47_RS14250 (MUO47_14235)	2853257..2853580	-	324	WP_001260485.1	helix-turn-helix transcriptional regulator	-
MUO47_RS14255 (MUO47_14240)	2853827..2853991	+	165	WP_277519332.1	hypothetical protein	-
MUO47_RS14260 (MUO47_14245)	2854007..2854252	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MUO47_RS14265 (MUO47_14250)	2854221..2854586	-	366	WP_001128433.1	hypothetical protein	Antitoxin
MUO47_RS14270 (MUO47_14255)	2854641..2854856	+	216	WP_001036302.1	hypothetical protein	-
MUO47_RS14275 (MUO47_14260)	2854881..2855144	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
MUO47_RS14280 (MUO47_14265)	2855157..2855318	+	162	WP_001285963.1	DUF1270 family protein	-
MUO47_RS14285 (MUO47_14270)	2855397..2855720	+	324	WP_000174994.1	hypothetical protein	-
MUO47_RS14290 (MUO47_14275)	2855735..2856097	+	363	WP_150868153.1	hypothetical protein	-
MUO47_RS14295 (MUO47_14280)	2856094..2857260	+	1167	WP_277445891.1	DUF2800 domain-containing protein	-
MUO47_RS14300 (MUO47_14285)	2857287..2857841	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2849728..2870849	21121

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T240736 WP_001025401.1 NZ_CP094923:2854007-2854252 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T240736 NZ_LT630450:c813338-813078 [Desulfovibrio piger]
ATGCTGCTGACCTGGACGTCCCAAGCGTGGGAAGATTATCTGTACTGGCAGGCGACCGACAAACGGACGGTGAAGCGCAT
CAATGAGTTGCTGCGTGATGCGCTCCGCAATCCGTTTGAAGGCCTTGGCAAGCCGGAGCCGCTCCGCTTTGACCTTGCGG
GATGCTGGTCCCGCCGCATCAATCAGGAAGACCGCCTTGTGTATCGCCTCGATGCGCAGGGGATGGCCCTGATCGTCCTC
CAGTGTCGCTACCACTACTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT240736 NZ_CP094923:c2854586-2854221 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin