Detailed information of TA system TA240733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1571306..1571805
• Replicon: chromosome
• Accession: NZ_CP094923
• Organism: Staphylococcus aureus strain 1824

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUO47_RS08090
• Protein ID: WP_000074044.1
• Coordinates: 1571306..1571548 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: MUO47_RS08095
• Protein ID: WP_000587618.1
• Coordinates: 1571548..1571805 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO47_RS08070 (MUO47_08060)	1566611..1567798	-	1188	WP_000026189.1	MFS transporter	-
MUO47_RS08075 (MUO47_08065)	1568194..1568970	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
MUO47_RS08080 (MUO47_08070)	1568963..1569625	-	663	WP_000923523.1	ATP-binding cassette domain-containing protein	-
MUO47_RS08085 (MUO47_08075)	1569873..1570949	-	1077	WP_001076672.1	M42 family metallopeptidase	-
MUO47_RS08090 (MUO47_08080)	1571306..1571548	-	243	WP_000074044.1	Txe/YoeB family addiction module toxin	Toxin
MUO47_RS08095 (MUO47_08085)	1571548..1571805	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUO47_RS08100 (MUO47_08090)	1572164..1572619	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
MUO47_RS08105 (MUO47_08095)	1572787..1574364	-	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
MUO47_RS08110 (MUO47_08100)	1574559..1575308	+	750	WP_000072459.1	CPBP family lipoprotein N-acylation protein LnsB	-
MUO47_RS08115 (MUO47_08105)	1575539..1576732	-	1194	WP_000675411.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9649.18 Da
• Isoelectric Point: 10.1469

>T240733 WP_000074044.1 NZ_CP094923:c1571548-1571306 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Nucleotide

• Length: 243 bp

>T240733 NZ_LT630287:c2497664-2497320 [Ligilactobacillus acidipiscis]
ATGGTAAGCCAAGGTGATATATTTTATGTTAACTTTAATCCAAGGCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCTCTAAGCAATGATCTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGTCAAACAGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTAGATTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGATAAATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT240733 WP_000587618.1 NZ_CP094923:c1571805-1571548 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT240733 NZ_LT630287:c2497921-2497658 [Ligilactobacillus acidipiscis]
ATGGAACTTATTAAAGAACAAACACGCTTAGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAACCAAGATATGACAATAACCATTGAAAATGGATCAATTGTTTTAACACCAATAAAAAAGA
ACCCAACCAATATTCACGAACTATTTAAGAATTGGCAAGATGACGGGAAAAGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGTAATGAACTTCAATGGTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2