Detailed information of TA system TA240731

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1539819..1540003
• Replicon: chromosome
• Accession: NZ_CP094923
• Organism: Staphylococcus aureus strain 1824

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUO47_RS07950
• Protein ID: WP_000482647.1
• Coordinates: 1539896..1540003 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1539819..1539879 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO47_RS07935 (MUO47_07925)	1535273..1535440	-	168	WP_001790576.1	hypothetical protein	-
MUO47_RS07940 (MUO47_07930)	1535671..1537404	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MUO47_RS07945 (MUO47_07935)	1537429..1539192	-	1764	WP_001064814.1	ABC transporter ATP-binding protein	-
-	1539819..1539879	+	61	-	-	Antitoxin
MUO47_RS07950 (MUO47_07940)	1539896..1540003	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUO47_RS07955 (MUO47_07945)	1540137..1540523	-	387	WP_000779360.1	flippase GtxA	-
MUO47_RS07960 (MUO47_07950)	1540781..1541923	+	1143	WP_001176863.1	glycerate kinase	-
MUO47_RS07965 (MUO47_07955)	1541983..1542642	+	660	WP_000831298.1	membrane protein	-
MUO47_RS07970 (MUO47_07960)	1542824..1544035	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MUO47_RS07975 (MUO47_07965)	1544158..1544631	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sbi / hlgA / hlgC / hlgB	1474595..1542642	68047

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240731 WP_000482647.1 NZ_CP094923:c1540003-1539896 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240731 NZ_LT615378:4445166-4445516 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240731 NZ_CP094923:1539819-1539879 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin