Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1471220..1471737 Replicon chromosome
Accession NZ_CP094923
Organism Staphylococcus aureus strain 1824

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag MUO47_RS07470 Protein ID WP_000113262.1
Coordinates 1471220..1471486 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUO47_RS07475 Protein ID WP_000584499.1
Coordinates 1471486..1471737 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO47_RS07440 (MUO47_07430) 1466641..1467177 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MUO47_RS07445 (MUO47_07435) 1467411..1468235 - 825 WP_000572040.1 formate/nitrite transporter family protein -
MUO47_RS07450 (MUO47_07440) 1468452..1468634 - 183 WP_000079142.1 hypothetical protein -
MUO47_RS07455 (MUO47_07445) 1468721..1469188 - 468 WP_000153344.1 SRPBCC domain-containing protein -
MUO47_RS07460 (MUO47_07450) 1469374..1470924 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUO47_RS07465 (MUO47_07455) 1471108..1471185 - 78 Protein_1435 hypothetical protein -
MUO47_RS07470 (MUO47_07460) 1471220..1471486 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
MUO47_RS07475 (MUO47_07465) 1471486..1471737 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUO47_RS07480 (MUO47_07470) 1471902..1472003 - 102 WP_031774922.1 hypothetical protein -
MUO47_RS07485 (MUO47_07475) 1472010..1472609 - 600 WP_000162813.1 DsbA family protein -
MUO47_RS07490 (MUO47_07480) 1472628..1472990 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUO47_RS07495 (MUO47_07485) 1473245..1474495 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
MUO47_RS07500 (MUO47_07490) 1474595..1475326 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUO47_RS07505 (MUO47_07495) 1475323..1476042 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T240729 WP_000113262.1 NZ_CP094923:c1471486-1471220 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240729 NZ_LT615378:c3696600-3696493 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240729 WP_000584499.1 NZ_CP094923:c1471737-1471486 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240729 NZ_LT615378:3696648-3696714 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References