Detailed information of TA system TA240706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2418921..2419438
• Replicon: chromosome
• Accession: NZ_CP094857
• Organism: Staphylococcus aureus strain ATCC 29213

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: MTX75_RS12095
• Protein ID: WP_000113265.1
• Coordinates: 2418921..2419187 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: MTX75_RS12100
• Protein ID: WP_000584499.1
• Coordinates: 2419187..2419438 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX75_RS12065 (2414349)	2414349..2414885	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
MTX75_RS12070 (2415119)	2415119..2415943	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
MTX75_RS12075 (2416160)	2416160..2416342	-	183	WP_000230292.1	hypothetical protein	-
MTX75_RS12080 (2416426)	2416426..2416893	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
MTX75_RS12085 (2417079)	2417079..2418626	-	1548	WP_000727756.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MTX75_RS12090 (2418815)	2418815..2418886	-	72	Protein_2337	hypothetical protein	-
MTX75_RS12095 (2418921)	2418921..2419187	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
MTX75_RS12100 (2419187)	2419187..2419438	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MTX75_RS12105 (2419603)	2419603..2419683	-	81	WP_223197974.1	hypothetical protein	-
MTX75_RS12110 (2419711)	2419711..2420310	-	600	WP_000162810.1	DsbA family protein	-
MTX75_RS12115 (2420329)	2420329..2420691	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
MTX75_RS12120 (2420946)	2420946..2422196	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
MTX75_RS12125 (2422293)	2422293..2423024	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
MTX75_RS12130 (2423021)	2423021..2423740	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T240706 WP_000113265.1 NZ_CP094857:c2419187-2418921 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T240706 NZ_LT615377:4445166-4445516 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT240706 WP_000584499.1 NZ_CP094857:c2419438-2419187 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT240706 NZ_LT615377:4444921-4445172 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60