Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2158958..2159174 Replicon chromosome
Accession NZ_CP094857
Organism Staphylococcus aureus strain ATCC 29213

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag MTX75_RS10740 Protein ID WP_001802298.1
Coordinates 2159070..2159174 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2158958..2159013 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX75_RS10715 2155107..2155772 - 666 WP_001024095.1 SDR family oxidoreductase -
MTX75_RS10720 2155924..2156244 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
MTX75_RS10725 2156246..2157223 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
MTX75_RS10730 2157489..2158580 + 1092 WP_000495669.1 hypothetical protein -
- 2158958..2159013 + 56 - - Antitoxin
MTX75_RS10740 2159070..2159174 - 105 WP_001802298.1 hypothetical protein Toxin
MTX75_RS10745 2159854..2160012 + 159 WP_001792784.1 hypothetical protein -
MTX75_RS10750 2160670..2161527 - 858 WP_031769139.1 HAD family hydrolase -
MTX75_RS10755 2161595..2162377 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T240704 WP_001802298.1 NZ_CP094857:c2159174-2159070 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T240704 NZ_LT615377:c3696600-3696493 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 56 bp

>AT240704 NZ_CP094857:2158958-2159013 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References