240693

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2674683..2675206 Replicon chromosome
Accession NZ_CP094855
Organism Staphylococcus aureus strain NY2491

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MTX64_RS13605 Protein ID WP_000074048.1
Coordinates 2674683..2674949 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MTX64_RS13610 Protein ID WP_000587616.1
Coordinates 2674949..2675206 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX64_RS13585 (2669990) 2669990..2671177 - 1188 WP_000026194.1 MFS transporter -
MTX64_RS13590 (2671573) 2671573..2672349 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
MTX64_RS13595 (2672342) 2672342..2673004 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
MTX64_RS13600 (2673252) 2673252..2674328 - 1077 WP_001076671.1 M42 family metallopeptidase -
MTX64_RS13605 (2674683) 2674683..2674949 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MTX64_RS13610 (2674949) 2674949..2675206 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTX64_RS13615 (2675565) 2675565..2676020 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MTX64_RS13620 (2676188) 2676188..2677765 - 1578 WP_000143501.1 FMN-binding glutamate synthase family protein -
MTX64_RS13625 (2677960) 2677960..2678709 + 750 WP_000072442.1 CPBP family lipoprotein N-acylation protein LnsB -
MTX64_RS13630 (2678933) 2678933..2680126 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240693 WP_000074048.1 NZ_CP094855:c2674949-2674683 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240693 NZ_LT615377:c1927043-1926940 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT240693 WP_000587616.1 NZ_CP094855:c2675206-2674949 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240693 NZ_LT615377:1926902-1927173 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References