240691

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2643183..2643367 Replicon chromosome
Accession NZ_CP094855
Organism Staphylococcus aureus strain NY2491

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag MTX64_RS13465 Protein ID WP_000482650.1
Coordinates 2643260..2643367 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2643183..2643243 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX64_RS13450 2638713..2638880 - 168 WP_001790576.1 hypothetical protein -
MTX64_RS13455 2639111..2640844 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
MTX64_RS13460 2640869..2642632 - 1764 WP_001064838.1 ABC transporter ATP-binding protein -
- 2643183..2643243 + 61 - - Antitoxin
MTX64_RS13465 2643260..2643367 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
MTX64_RS13470 2643501..2643887 - 387 WP_000779358.1 flippase GtxA -
MTX64_RS13475 2644155..2645297 + 1143 WP_001176863.1 glycerate kinase -
MTX64_RS13480 2645357..2646016 + 660 WP_000831298.1 membrane protein -
MTX64_RS13485 2646198..2647409 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MTX64_RS13490 2647532..2648005 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T240691 WP_000482650.1 NZ_CP094855:c2643367-2643260 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240691 NZ_LT615377:1512940-1513116 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 61 bp

>AT240691 NZ_CP094855:2643183-2643243 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References