240690

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2617831..2618348 Replicon chromosome
Accession NZ_CP094855
Organism Staphylococcus aureus strain NY2491

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag MTX64_RS13330 Protein ID WP_000113262.1
Coordinates 2617831..2618097 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MTX64_RS13335 Protein ID WP_000584499.1
Coordinates 2618097..2618348 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX64_RS13300 (2613257) 2613257..2613793 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MTX64_RS13305 (2614026) 2614026..2614850 - 825 WP_000572040.1 formate/nitrite transporter family protein -
MTX64_RS13310 (2615067) 2615067..2615249 - 183 WP_000230294.1 hypothetical protein -
MTX64_RS13315 (2615333) 2615333..2615800 - 468 WP_000153344.1 SRPBCC domain-containing protein -
MTX64_RS13320 (2615986) 2615986..2617536 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MTX64_RS13325 (2617725) 2617725..2617796 - 72 Protein_2589 hypothetical protein -
MTX64_RS13330 (2617831) 2617831..2618097 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
MTX64_RS13335 (2618097) 2618097..2618348 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTX64_RS13340 (2618513) 2618513..2618614 - 102 WP_001791744.1 hypothetical protein -
MTX64_RS13345 (2618621) 2618621..2619220 - 600 WP_000162813.1 DsbA family protein -
MTX64_RS13350 (2619239) 2619239..2619601 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MTX64_RS13355 (2619856) 2619856..2621106 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
MTX64_RS13360 (2621203) 2621203..2621934 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MTX64_RS13365 (2621931) 2621931..2622650 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T240690 WP_000113262.1 NZ_CP094855:c2618097-2617831 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240690 NZ_LT615377:c1297765-1297658 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240690 WP_000584499.1 NZ_CP094855:c2618348-2618097 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240690 NZ_LT615377:1297812-1297878 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References