Detailed information of TA system TA240688

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2346189..2346452
• Replicon: chromosome
• Accession: NZ_CP094855
• Organism: Staphylococcus aureus strain NY2491

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: MTX64_RS11915
• Protein ID: WP_001802298.1
• Coordinates: 2346348..2346452 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2346189..2346353 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX64_RS11890	2342372..2343037	-	666	WP_001024094.1	SDR family oxidoreductase	-
MTX64_RS11895	2343189..2343509	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MTX64_RS11900	2343511..2344491	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
MTX64_RS11905	2344757..2345848	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2346189..2346353	+	165	-	-	Antitoxin
MTX64_RS11915	2346348..2346452	-	105	WP_001802298.1	hypothetical protein	Toxin
MTX64_RS11920	2346613..2347096	-	484	Protein_2317	recombinase family protein	-
MTX64_RS11925	2347139..2348275	-	1137	WP_000115564.1	SAP domain-containing protein	-
MTX64_RS11930	2348564..2348656	+	93	WP_031872195.1	hypothetical protein	-
MTX64_RS11940	2349361..2350218	-	858	WP_000370924.1	HAD family hydrolase	-
MTX64_RS11945	2350286..2351068	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T240688 WP_001802298.1 NZ_CP094855:c2346452-2346348 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T240688 NZ_LT615377:c1296695-1296588 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT240688 NZ_CP094855:2346189-2346353 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin