Detailed information of TA system TA240678

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2109779..2110078
• Replicon: chromosome
• Accession: NZ_CP094855
• Organism: Staphylococcus aureus strain NY2491

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: MTX64_RS10525
• Protein ID: WP_072482930.1
• Coordinates: 2109902..2110078 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2109779..2109834 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX64_RS10485	2105338..2105517	+	180	WP_000669789.1	hypothetical protein	-
MTX64_RS10490	2105828..2106088	+	261	WP_001791826.1	hypothetical protein	-
MTX64_RS10495	2106141..2106491	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
MTX64_RS10500	2106999..2107334	-	336	Protein_2035	SH3 domain-containing protein	-
MTX64_RS10505	2107987..2108478	-	492	WP_000920041.1	staphylokinase	-
MTX64_RS10510	2108669..2109424	-	756	WP_000861038.1	CHAP domain-containing protein	-
MTX64_RS10515	2109436..2109690	-	255	WP_000611512.1	phage holin	-
MTX64_RS10520	2109742..2109849	+	108	Protein_2039	hypothetical protein	-
-	2109771..2109910	+	140	NuclAT_0	-	-
-	2109771..2109910	+	140	NuclAT_0	-	-
-	2109771..2109910	+	140	NuclAT_0	-	-
-	2109771..2109910	+	140	NuclAT_0	-	-
-	2109779..2109834	+	56	-	-	Antitoxin
MTX64_RS10525	2109902..2110078	-	177	WP_072482930.1	type I toxin-antitoxin system toxin PepG1	Toxin
MTX64_RS10530	2110187..2110960	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
MTX64_RS10535	2111333..2111707	-	375	WP_000340977.1	hypothetical protein	-
MTX64_RS10540	2111763..2112050	-	288	WP_001262621.1	hypothetical protein	-
MTX64_RS10545	2112096..2112248	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / selq / selk	2106141..2195453	89312

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T240678 WP_072482930.1 NZ_CP094855:c2110078-2109902 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T240678 NZ_LT615367:528446-528721 [Dickeya aquatica]
ATGGAAATACTTTGGACACAAAAGGCACAGGATGACCTAGAGCGCATTTATCGGTTTGCCAGCCAGTACAGTCGGCAGCA
TGCTGACGATGTGTTAGATCGCCTGTTCATCGGAACAACAGAGCTTGTTGATCATCCAAGAATCGGTGTATCTCAGACAA
GATATGAACCCCGTGAGGTGAGAAAAATTCTGTTTGATGATTACGAGGTTCACTATGAAATTCAGCACAACACTATTTAT
ATCGTCGATTTGTGGCATACACGAGAAGATCGCTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT240678 NZ_CP094855:2109779-2109834 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin