Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2627342..2627865 Replicon chromosome
Accession NZ_CP094853
Organism Staphylococcus aureus strain NY2010

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MTX62_RS13290 Protein ID WP_000074048.1
Coordinates 2627342..2627608 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MTX62_RS13295 Protein ID WP_000587616.1
Coordinates 2627608..2627865 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX62_RS13270 (2622649) 2622649..2623836 - 1188 WP_000026194.1 MFS transporter -
MTX62_RS13275 (2624232) 2624232..2625008 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
MTX62_RS13280 (2625001) 2625001..2625663 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
MTX62_RS13285 (2625911) 2625911..2626987 - 1077 WP_001076671.1 M42 family metallopeptidase -
MTX62_RS13290 (2627342) 2627342..2627608 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MTX62_RS13295 (2627608) 2627608..2627865 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTX62_RS13300 (2628224) 2628224..2628679 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MTX62_RS13305 (2628847) 2628847..2630424 - 1578 WP_000143501.1 FMN-binding glutamate synthase family protein -
MTX62_RS13310 (2630619) 2630619..2631368 + 750 WP_000072442.1 CPBP family lipoprotein N-acylation protein LnsB -
MTX62_RS13315 (2631592) 2631592..2632785 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240674 WP_000074048.1 NZ_CP094853:c2627608-2627342 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240674 NZ_LT615228:c887606-887208 [Polynucleobacter necessarius]
ATGCTGAAGTACTTGCTCGATACCAACATTGTTATTTATGTAATGAAGAGAAAACCGCTTGAGGTGCTTAAGGTCTTCAA
TAAAAATGCAAACCGAATGGCTATATCAACAATTACGTTGGCGGAGTTGATGTATGGTGCAGAAAAGAGTCAACAGGTTG
AAAGTAATCTCAATAACATTGAAGATTTTGTAAGTCACTTAGAAGTTTTACCGTATGACATATATGCAACTCAGCATTAT
GGTCAAATCAAAGCGTTCTTGGAAAGCACGGGTAAACCTATTGGAGTGAATGATATTCATATTGCGGCTCATGCTAGAAG
TCACGGTTTAACCCTAGTAACTAATAATCTATCGGAATTTAAAAGAGTCCCCAATCTTGCCCTTGAGAATTGGGTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT240674 WP_000587616.1 NZ_CP094853:c2627865-2627608 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240674 NZ_LT615228:c887839-887606 [Polynucleobacter necessarius]
ATGGCTATTTCAACTGTTTTTACAAATAACAGGACCCAAGCTGTGAGATTGCCCGCTGAAATGCGGCTGCCAGAAAATGT
GCGCAAGGTTAATGTCCGCGCAAAGGGTCGGGAACGAATAATTGCCCCTATTGAGAATATGTGGGATAACTACTTTTTGG
GCGATGCTCGTGTGAGTGACGATTTTATGAATGAAAGAGGTTCTCAAGAGCAAAGTGATAGAGAGCCCCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References