Detailed information of TA system TA240672

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2595842..2596026
• Replicon: chromosome
• Accession: NZ_CP094853
• Organism: Staphylococcus aureus strain NY2010

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: MTX62_RS13150
• Protein ID: WP_000482650.1
• Coordinates: 2595919..2596026 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2595842..2595902 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX62_RS13135	2591372..2591539	-	168	WP_001790576.1	hypothetical protein	-
MTX62_RS13140	2591770..2593503	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MTX62_RS13145	2593528..2595291	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2595842..2595902	+	61	-	-	Antitoxin
MTX62_RS13150	2595919..2596026	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
MTX62_RS13155	2596160..2596546	-	387	WP_000779358.1	flippase GtxA	-
MTX62_RS13160	2596814..2597956	+	1143	WP_001176863.1	glycerate kinase	-
MTX62_RS13165	2598016..2598675	+	660	WP_000831298.1	membrane protein	-
MTX62_RS13170	2598857..2600068	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MTX62_RS13175	2600191..2600664	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T240672 WP_000482650.1 NZ_CP094853:c2596026-2595919 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240672 NZ_LT615218:c2477178-2476912 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTATTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240672 NZ_CP094853:2595842-2595902 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin