Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2570490..2571007 Replicon chromosome
Accession NZ_CP094853
Organism Staphylococcus aureus strain NY2010

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag MTX62_RS13015 Protein ID WP_000113262.1
Coordinates 2570490..2570756 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MTX62_RS13020 Protein ID WP_000584499.1
Coordinates 2570756..2571007 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX62_RS12985 (2565916) 2565916..2566452 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MTX62_RS12990 (2566685) 2566685..2567509 - 825 WP_000572040.1 formate/nitrite transporter family protein -
MTX62_RS12995 (2567726) 2567726..2567908 - 183 WP_000230294.1 hypothetical protein -
MTX62_RS13000 (2567992) 2567992..2568459 - 468 WP_000153344.1 SRPBCC domain-containing protein -
MTX62_RS13005 (2568645) 2568645..2570195 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MTX62_RS13010 (2570384) 2570384..2570455 - 72 Protein_2528 hypothetical protein -
MTX62_RS13015 (2570490) 2570490..2570756 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
MTX62_RS13020 (2570756) 2570756..2571007 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTX62_RS13025 (2571172) 2571172..2571273 - 102 WP_001791744.1 hypothetical protein -
MTX62_RS13030 (2571280) 2571280..2571879 - 600 WP_000162813.1 DsbA family protein -
MTX62_RS13035 (2571898) 2571898..2572260 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MTX62_RS13040 (2572515) 2572515..2573765 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
MTX62_RS13045 (2573862) 2573862..2574593 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MTX62_RS13050 (2574590) 2574590..2575309 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T240671 WP_000113262.1 NZ_CP094853:c2570756-2570490 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240671 NZ_LT615218:c2445548-2445441 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240671 WP_000584499.1 NZ_CP094853:c2571007-2570756 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240671 NZ_LT615218:2445364-2445424 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References