Detailed information of TA system TA240670

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2301674..2301891
• Replicon: chromosome
• Accession: NZ_CP094853
• Organism: Staphylococcus aureus strain NY2010

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: MTX62_RS11610
• Protein ID: WP_001802298.1
• Coordinates: 2301787..2301891 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2301674..2301729 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX62_RS11585	2297811..2298476	-	666	WP_001024094.1	SDR family oxidoreductase	-
MTX62_RS11590	2298628..2298948	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MTX62_RS11595	2298950..2299930	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
MTX62_RS11600	2300196..2301287	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2301674..2301729	+	56	-	-	Antitoxin
MTX62_RS11610	2301787..2301891	-	105	WP_001802298.1	hypothetical protein	Toxin
MTX62_RS11615	2302052..2302535	-	484	Protein_2258	recombinase family protein	-
MTX62_RS11620	2302578..2303714	-	1137	WP_000115564.1	SAP domain-containing protein	-
MTX62_RS11625	2304003..2304095	+	93	WP_031872195.1	hypothetical protein	-
MTX62_RS11635	2304800..2305657	-	858	WP_000370924.1	HAD family hydrolase	-
MTX62_RS11640	2305725..2306507	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T240670 WP_001802298.1 NZ_CP094853:c2301891-2301787 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T240670 NZ_LT615218:c2164451-2164347 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT240670 NZ_CP094853:2301674-2301729 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin