Detailed information of TA system TA240659

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2065242..2065541
• Replicon: chromosome
• Accession: NZ_CP094853
• Organism: Staphylococcus aureus strain NY2010

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: MTX62_RS10210
• Protein ID: WP_072482930.1
• Coordinates: 2065365..2065541 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2065242..2065297 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX62_RS10170	2060799..2060978	+	180	WP_000669789.1	hypothetical protein	-
MTX62_RS10175	2061289..2061549	+	261	WP_001791826.1	hypothetical protein	-
MTX62_RS10180	2061602..2061952	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
MTX62_RS10185	2062462..2062797	-	336	Protein_1975	SH3 domain-containing protein	-
MTX62_RS10190	2063450..2063941	-	492	WP_000920041.1	staphylokinase	-
MTX62_RS10195	2064132..2064887	-	756	WP_000861038.1	CHAP domain-containing protein	-
MTX62_RS10200	2064899..2065153	-	255	WP_000611512.1	phage holin	-
MTX62_RS10205	2065205..2065312	+	108	Protein_1979	hypothetical protein	-
-	2065234..2065373	+	140	NuclAT_0	-	-
-	2065234..2065373	+	140	NuclAT_0	-	-
-	2065234..2065373	+	140	NuclAT_0	-	-
-	2065234..2065373	+	140	NuclAT_0	-	-
-	2065242..2065297	+	56	-	-	Antitoxin
MTX62_RS10210	2065365..2065541	-	177	WP_072482930.1	type I toxin-antitoxin system toxin PepG1	Toxin
MTX62_RS10215	2065650..2066423	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
MTX62_RS10220	2066796..2067170	-	375	WP_000340977.1	hypothetical protein	-
MTX62_RS10225	2067226..2067513	-	288	WP_001262621.1	hypothetical protein	-
MTX62_RS10230	2067559..2067711	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / selq / selk	2061602..2150908	89306

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T240659 WP_072482930.1 NZ_CP094853:c2065541-2065365 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T240659 NZ_LT608330:1887458-1888045 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTTGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT240659 NZ_CP094853:2065242-2065297 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin