240649

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1423941..1424879 Replicon chromosome
Accession NZ_CP094846
Organism Ornithobacterium rhinotracheale strain K223

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag MT996_RS06720 Protein ID WP_153828723.1
Coordinates 1424343..1424879 (+) Length 179 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag MT996_RS06715 Protein ID WP_243910167.1
Coordinates 1423941..1424258 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT996_RS06690 (MT996_06690) 1419145..1420005 - 861 WP_153828728.1 outer membrane protein assembly factor BamD -
MT996_RS06695 (MT996_06695) 1420179..1420532 - 354 WP_153828727.1 hypothetical protein -
MT996_RS06700 (MT996_06700) 1420572..1421162 - 591 WP_153828726.1 sugar transferase -
MT996_RS06705 (MT996_06705) 1421276..1423495 - 2220 WP_153828725.1 NADP-dependent isocitrate dehydrogenase -
MT996_RS06710 (MT996_06710) 1423732..1423929 + 198 WP_153828724.1 helix-turn-helix transcriptional regulator -
MT996_RS06715 (MT996_06715) 1423941..1424258 + 318 WP_243910167.1 HipA N-terminal domain-containing protein Antitoxin
MT996_RS06720 (MT996_06720) 1424343..1424879 + 537 WP_153828723.1 HipA domain-containing protein Toxin
MT996_RS06725 (MT996_06725) 1424955..1425965 - 1011 WP_243910071.1 NAD(P)-dependent oxidoreductase -
MT996_RS06730 (MT996_06730) 1426254..1426862 - 609 WP_153828721.1 hypothetical protein -
MT996_RS06735 (MT996_06735) 1427172..1427678 + 507 WP_153828720.1 C40 family peptidase -
MT996_RS06740 (MT996_06740) 1427675..1429486 - 1812 WP_153828719.1 chloride channel protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(30-172)

Antitoxin

HipA, N-terminal subdomain 1

(5-102)


Sequences

Toxin        


Download         Length: 179 a.a.        Molecular weight: 20669.08 Da        Isoelectric Point: 8.9321

>T240649 WP_153828723.1 NZ_CP094846:1424343-1424879 [Ornithobacterium rhinotracheale]
MFGTENPPILELNHNELQKIAKEIIVKSIAVTGVQPKLSLQLSKNTKDAPRLTLVGPYGDYILKPQTEHYSELPENEDLT
MHLAELAKIKIVKHTLIRLQSRELAYITQRFDRIKGKKIAVEDFCQLSENMTEHKYRSSVEKVGILTYQFTTNKGFELQR
LFELILFNVCMHSRFFFV

Download         Length: 537 bp

>T240649 NZ_LT605586:c446148-445867 [Brucella inopinata]
ATGATCCGATCTTACAAGAACAGCGTCACTGAAACCGTGGCGTGGGGTAAAGCTCCAAAAGGGTTCCCATCTGATCTTGT
CCGGGTATCAGTTCGTAAGCTCACCATGCTCGACAACGCAGTAACCCTTGATGATCTTCGCTCCCCACCGGGAAATCGGC
TTGAAGCTCTCAAGGGCGACCGCCAAGGTCAGCATTCAATCCGCATAAACGACCAGTGGCGCATCTGCTTTGTCTGGACA
GATGCTGGCGCTGAACAGGTTGAAATCGTAGATTATCACTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12059.09 Da        Isoelectric Point: 5.8546

>AT240649 WP_243910167.1 NZ_CP094846:1423941-1424258 [Ornithobacterium rhinotracheale]
IIRQAEVFYHNSLAGTIEENENGFIFKYDEDYLKSEKVKPISLTLPLQEKPYESKILFPFFDGLIPEGWLLNIAVKNCKL
NPRDRFGLLLSMCKDCIGCVSIISK

Download         Length: 318 bp

>AT240649 NZ_LT605586:c445854-445558 [Brucella inopinata]
ATGACCAATATCCTTCCTCCGGTCCACCCCGGCGAAATCCTTCGGGAAGAATATCTCATCCCGCTTGGTATGAGCGCGGG
CGCACTCGCCAAGCGTCTGAATGTCCCTCGCACACGCATCGAGCGTCTGGCTACAGAACAAACGAACGTCACCCCGGATA
CTGCCCTGCGCCTTGCCAAGTTCCTCCGCACTACACCGGAATTCTGGATGAATATGCAGGCGAGTTATGACCTAAAAACG
GAGGCCGTCGCCATTCAGGACCAACTTGCAGCGATCCACGAGATGGAAGCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References