240624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 69017..69530 Replicon chromosome
Accession NZ_CP094824
Organism Mammaliicoccus sciuri strain IVB6216

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA60_RS00315 Protein ID WP_262649063.1
Coordinates 69264..69530 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA60_RS00310 Protein ID WP_084756271.1
Coordinates 69017..69271 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA60_RS00280 (MUA60_00280) 64101..64658 + 558 WP_262649059.1 hypothetical protein -
MUA60_RS00285 (MUA60_00285) 64792..65466 - 675 WP_262648940.1 IS6-like element IS257 family transposase -
MUA60_RS00290 (MUA60_00290) 65496..65645 - 150 WP_262649060.1 hypothetical protein -
MUA60_RS00295 (MUA60_00295) 65800..66225 + 426 WP_048540369.1 MerR family transcriptional regulator -
MUA60_RS00300 (MUA60_00300) 66287..67135 + 849 WP_262649061.1 aldo/keto reductase -
MUA60_RS00310 (MUA60_00310) 69017..69271 + 255 WP_084756271.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MUA60_RS00315 (MUA60_00315) 69264..69530 + 267 WP_262649063.1 Txe/YoeB family addiction module toxin Toxin
MUA60_RS00320 (MUA60_00320) 69689..70027 + 339 WP_048540373.1 hypothetical protein -
MUA60_RS00325 (MUA60_00325) 70060..70950 - 891 WP_262649065.1 ABC transporter permease subunit -
MUA60_RS00330 (MUA60_00330) 70947..71801 - 855 WP_107610253.1 ABC transporter permease subunit -
MUA60_RS00335 (MUA60_00335) 71970..72443 - 474 WP_107610254.1 GNAT family N-acetyltransferase -
MUA60_RS00340 (MUA60_00340) 73004..73567 - 564 WP_262649068.1 phosphoglycerate mutase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10479.15 Da        Isoelectric Point: 9.6422

>T240624 WP_262649063.1 NZ_CP094824:69264-69530 [Mammaliicoccus sciuri]
MSKRNIIFTPTAFEDYEYWLAQDKKLLKKINSLIKSIQRDGQLEGEGKPEPLKGNLQGYCSRRINHEHRLVYMVKENHII
IIGCRYHY

Download         Length: 267 bp

>T240624 NZ_LT601384:2142594-2143250 [Escherichia coli]
ATGGCTTATGATTACAGCGCCAGCCTCAACCCGCAAAAAGCTCTGATCTGGCGTATCGTCCATCGGGACAATATCCCGTG
GATTCTGGATAACGGGCTGCACTGCGGCAACAGTCTGGTGCAGGCGGAAAACTGGATCAATATCGGCAACCCGGAGCTGA
TCGGCAAGCGTGCCGGGCATCCGGTACCTGTCGGAACGGGCGGGACACTGCATGACTATGTGCCGTTTTATTTTACCCCC
TTCTCGCCAATGCTGATGAACATCCACAGCGGGCGCGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGCAACTTGCGAAACGTGGCAGCACACGACGTACCCTTCGTGTTTACCGACAGCCATGCTTACTATAACTGGACCAACT
ACTACACCAGTCTGGATAGTCTGGACCAGATCGACTGGCCCATTTTGCAGGCACGGGACTTTCGCCGCGATCCAGACGAT
CCGGCTAAATTTGAACGCTATCAGGCAGAGGCGCTAATCTGGCAACACTGCCCGATCTCTCTGCTGGATGGGATAATTTG
TTACAGCGAAGAGGTCAGGTTACAATTAGAACAATGGCTGTTTCAGCGTAATCTAACAATGTCCGTTCACACACGGGCTG
GATGGTACTTCTCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9433.33 Da        Isoelectric Point: 4.1064

>AT240624 WP_084756271.1 NZ_CP094824:69017-69271 [Mammaliicoccus sciuri]
MTVISYSNARKNFRKLIDKVNNDSDTVTITTNESNAVLMGEDDYNSIMETLYLQQSPANAKHLAKSIEEAEGNNTVEVDI
ESYE

Download         Length: 255 bp

>AT240624 NZ_LT601384:2143247-2144314 [Escherichia coli]
ATGATCACATATACACAAGGCAATTTACTGGACGCACCGGTGGAAGCTCTGGTGAATACGGTTAATACCGTCGGTGTCAT
GGGGAAAGGCATCGCGTTGATGTTTAAAGAGCGCTTCCCCGAAAATATGAAAGTCTATGCCCTCGCCTGCAAACAAAAGC
AGGTGATCACCGGCAAAATGTTCATTACCGAAACCGGGGAACTGATGGGACCGCGCTGGATTGTTAATTTTCCGACCAAA
CAGCACTGGCGCGCTGATTCCCGCATGGAGTGGATTGAAGATGGCTTGCAGGACTTACGCCGCTTTTTGATTGAAGAGAA
CGTGCAGTCCATCGCCATTCCACCACTGGGCGCAGGCAACGGTGGTTTGAACTGGCCGGACGTTCGGGCGCAGATTGAAT
CTGCCCTTGGCGACCTTCAGGACGTTGATATCCTGATTTACCAACCGACTGAAAAATACCAGAACGTTGCCAAAAGCACT
GGCGTAAAAAAGCTCACTCCCGCCAGAGCCGCCATCGCTGAACTGGTGCGTCGCTACTGGGTATTGGGGATGGAGTGCAG
CCTACTGGAAATCCAGAAACTGGCCTGGCTGTTACAACGCGCCATTGAGCAGCATCAACAGGACGATATCCTCAAACTGC
GGTTTGAAGCTCACTATTATGGCCCCTATGCGCCCAATCTGAACCATCTGCTTAATGCGCTGGACGGCACCTATCTTAAA
GCCGAGAAACGCATCCCGGACAGCCAACCGCTGGATGTGATCTGGTTTAACGATCAGAAAAAAGAACACGTTAATGCGTA
TCTGAACAACGAAGCCAGAGAGTGGCTACCTGCGCTGGAGCAGGTCAGCCAGTTAATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGTTGCTGGCAACCGTAGACTGGTTGCTGAGCCGTGGCGAATGTCAACCAACGCTGGATTCCGTTAAGGAAGGG
CTGCACCAGTGGCCTGCGGGCGAACGCTGGGCCAGCCGTAAGTTGAGGCTGTTTGATAATAATAATCTGCAATTTGCCAT
TAACCGCGTAATGGAGTTCCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References