240621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 98094..98607 Replicon chromosome
Accession NZ_CP094823
Organism Mammaliicoccus sciuri strain IVB6217

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA76_RS00415 Protein ID WP_243547843.1
Coordinates 98341..98607 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA76_RS00410 Protein ID WP_243523231.1
Coordinates 98094..98348 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA76_RS00385 (MUA76_00385) 94147..94887 + 741 WP_262651056.1 CRISPR-associated endoribonuclease Cas6 -
MUA76_RS00390 (MUA76_00390) 94939..95793 - 855 WP_262651057.1 BlaZ-like penicillin-hydrolyzing class A beta-lactamase -
MUA76_RS00395 (MUA76_00395) 95931..96248 + 318 WP_037589651.1 metalloregulator ArsR/SmtB family transcription factor -
MUA76_RS00400 (MUA76_00400) 96327..97250 + 924 WP_262651058.1 NAD-dependent epimerase/dehydratase family protein -
MUA76_RS00405 (MUA76_00405) 97252..97947 + 696 WP_262651060.1 type 1 glutamine amidotransferase domain-containing protein -
MUA76_RS00410 (MUA76_00410) 98094..98348 + 255 WP_243523231.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA76_RS00415 (MUA76_00415) 98341..98607 + 267 WP_243547843.1 Txe/YoeB family addiction module toxin Toxin
MUA76_RS00420 (MUA76_00420) 98766..99104 + 339 WP_049320177.1 hypothetical protein -
MUA76_RS00425 (MUA76_00425) 99163..99636 - 474 WP_262651061.1 GNAT family N-acetyltransferase -
MUA76_RS00430 (MUA76_00430) 99786..100145 - 360 WP_262651063.1 hypothetical protein -
MUA76_RS00435 (MUA76_00435) 100527..101357 + 831 WP_262651064.1 CPBP family intramembrane metalloprotease -
MUA76_RS00440 (MUA76_00440) 101580..101909 + 330 WP_262651066.1 hypothetical protein -
MUA76_RS00445 (MUA76_00445) 102307..102498 - 192 WP_262651067.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10450.95 Da        Isoelectric Point: 9.3660

>T240621 WP_243547843.1 NZ_CP094823:98341-98607 [Mammaliicoccus sciuri]
MSKRNITFTPSASEDYEYWLEQDKKLLKKINSLIKSIQRDSQLEGEGKPEPLKGNLQGYCSRRINHEHRLVYTVKENHII
IIGCRYHY

Download         Length: 267 bp

>T240621 NZ_LT601384:1732109-1732216 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9558.55 Da        Isoelectric Point: 4.2213

>AT240621 WP_243523231.1 NZ_CP094823:98094-98348 [Mammaliicoccus sciuri]
MTVISYSNARKNFRKLIDKVNNDSDIVTITTNESNAVLMGEDDYNSIMETLYLQQSPANAKHLAKSIEEAERNNTVEIDI
ESYE

Download         Length: 255 bp

>AT240621 NZ_LT601384:c1732059-1731996 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References